CRCGN016_MCF10A.WT.HP_24H:M09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description beta testosterone 11.03 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

90 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:M09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KLHL21 kelch-like family member 21 5.12265
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.80735
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.77465
KLHL9 kelch-like family member 9 4.4633
CRELD2 cysteine-rich with EGF-like domains 2 3.6694
KDM5A lysine (K)-specific demethylase 5A 3.4125
IDE insulin-degrading enzyme 3.29535
NRBF2 nuclear receptor binding factor 2 3.21795
RNF111 ring finger protein 111 3.1988
ACLY ATP citrate lyase 3.01682
TSPAN8 tetraspanin 8 2.76875
PDLIM1 PDZ and LIM domain 1 2.73255
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.6634
CTNNBIP1 catenin, beta interacting protein 1 2.5884
CYREN cell cycle regulator of NHEJ 2.55015
NUP205 nucleoporin 205kDa 2.54525
TMEM70 transmembrane protein 70 2.5206
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11 2.5117
MAOB monoamine oxidase B 2.51035
ACTA2 actin, alpha 2, smooth muscle, aorta 2.42845
USP6 ubiquitin specific peptidase 6 2.41165
SYNPO synaptopodin 2.4094
FBXL12 F-box and leucine-rich repeat protein 12 2.402
TRAPPC4 trafficking protein particle complex 4 2.37915
AGR2 anterior gradient 2 2.34335
PPP1R3D protein phosphatase 1, regulatory subunit 3D 2.29865
CCDC6 coiled-coil domain containing 6 2.2915
UNC13D unc-13 homolog D (C. elegans) 2.27665
PANK4 pantothenate kinase 4 2.25455
ALKBH1 alkB, alkylation repair homolog 1 (E. coli) 2.24195
CSTF2T cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant 2.23322
H2AX H2A.X variant histone 2.22985
MSANTD2 Myb/SANT-like DNA-binding domain containing 2 2.2291
TRIM24 tripartite motif containing 24 2.17905
SDF4 stromal cell derived factor 4 2.16393
ANXA11 annexin A11 2.15293
FXYD1 FXYD domain containing ion transport regulator 1 2.1468
LEMD3 LEM domain containing 3 2.142
GCC1 GRIP and coiled-coil domain containing 1 2.1326
KBTBD2 kelch repeat and BTB (POZ) domain containing 2 2.1205
AGK acylglycerol kinase 2.11643
ZKSCAN7 zinc finger with KRAB and SCAN domains 7 2.0887
CUL1 cullin 1 2.08045
SEC24B SEC24 family member B 2.0676
ABRAXAS2 abraxas 2, BRISC complex subunit 2.06043
ZNF202 zinc finger protein 202 2.0464
ABHD18 abhydrolase domain containing 18 2.0459
JHY junctional cadherin complex regulator 2.0392
ZMYM3 zinc finger, MYM-type 3 2.0348
RIDA reactive intermediate imine deaminase A homolog 2.03245
ACO2 aconitase 2, mitochondrial 2.02305
MYOZ3 myozenin 3 2.0219
MYOM1 myomesin 1 2.0188

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -6.11975
KIF14 kinesin family member 14 -5.50965
RNF167 ring finger protein 167 -5.50785
CASC3 cancer susceptibility candidate 3 -5.35855
PCCB propionyl CoA carboxylase, beta polypeptide -5.2089
BASP1 brain abundant, membrane attached signal protein 1 -4.82765
ARID4B AT rich interactive domain 4B (RBP1-like) -3.5162
RBM34 RNA binding motif protein 34 -3.42727
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -3.22182
CBR3 carbonyl reductase 3 -3.2207
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.16103
CRTAP cartilage associated protein -2.9845
LAPTM4A lysosomal protein transmembrane 4 alpha -2.8089
TBX3 T-box 3 -2.62255
CD9 CD9 molecule -2.58205
OSTM1 osteopetrosis associated transmembrane protein 1 -2.58045
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein -2.4744
EIPR1 EARP complex and GARP complex interacting protein 1 -2.46025
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae) -2.40865
EIF4A2 eukaryotic translation initiation factor 4A2 -2.3827
RPL6 ribosomal protein L6 -2.3728
C1QBP complement component 1, q subcomponent binding protein -2.36493
CAMLG calcium modulating ligand -2.3465
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.3448
TBCE tubulin folding cofactor E -2.32465
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -2.3016
TOMM34 translocase of outer mitochondrial membrane 34 -2.29835
HLTF helicase-like transcription factor -2.293
MT1X metallothionein 1X -2.26595
MED24 mediator complex subunit 24 -2.16875
DNM3 dynamin 3 -2.1522
HAUS4 HAUS augmin-like complex, subunit 4 -2.13635
USP21 ubiquitin specific peptidase 21 -2.05655
ASPSCR1 alveolar soft part sarcoma chromosome region, candidate 1 -2.053
EMC3 ER membrane protein complex subunit 3 -2.04295
CCT3 chaperonin containing TCP1, subunit 3 (gamma) -2.02745
PFDN2 prefoldin subunit 2 -2.0179