CRCGN016_MCF10A.WT.HP_24H:M15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzo(b)fluoranthene 10.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:M15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IL1B interleukin 1, beta 3.91558
ACAA1 acetyl-CoA acyltransferase 1 3.47368
GPER1 G protein-coupled estrogen receptor 1 3.16074
BTK Bruton agammaglobulinemia tyrosine kinase 3.05016
PDIA5 protein disulfide isomerase family A, member 5 2.92426
CXCR4 chemokine (C-X-C motif) receptor 4 2.80817
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.63309
HBA1 hemoglobin, alpha 1 2.40879
ZBTB35 zinc finger and BTB domain containing 35 2.3545
SQOR sulfide quinone oxidoreductase 2.34259

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -6.61823
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.36093
HACD3 3-hydroxyacyl-CoA dehydratase 3 -3.35388
KIF14 kinesin family member 14 -3.28526
S100A8 S100 calcium binding protein A8 -3.16808
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.16558
LDHD lactate dehydrogenase D -3.09692
NUSAP1 nucleolar and spindle associated protein 1 -3.0093
CD58 CD58 molecule -2.97611
MELK maternal embryonic leucine zipper kinase -2.82539
HAT1 histone acetyltransferase 1 -2.81547
RPA3 replication protein A3, 14kDa -2.79107
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.74614
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.72727
NR2F6 nuclear receptor subfamily 2, group F, member 6 -2.66313
PUF60 poly-U binding splicing factor 60KDa -2.46703
TRIB3 tribbles pseudokinase 3 -2.38586
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.27506
HEATR1 HEAT repeat containing 1 -2.26388
VAT1 vesicle amine transport 1 -2.22724
BID BH3 interacting domain death agonist -2.20211
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.15159
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.13862
GTPBP3 GTP binding protein 3 (mitochondrial) -2.03173