CRCGN016_MCF10A.WT.HP_24H:M16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorphenamine 99.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:M16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ZMIZ1 zinc finger, MIZ-type containing 1 6.94297
ACAA1 acetyl-CoA acyltransferase 1 4.62713
WASF3 WAS protein family, member 3 4.6193
MNAT1 MNAT CDK-activating kinase assembly factor 1 4.51082
CHEK1 checkpoint kinase 1 4.40541
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.99461
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.92216
KIF5C kinesin family member 5C 3.70107
GRB10 growth factor receptor-bound protein 10 3.41967
HMOX1 heme oxygenase 1 3.22233
ZFP36 ZFP36 ring finger protein 2.2958
OLFML2B olfactomedin-like 2B 2.28812
PBX3 pre-B-cell leukemia homeobox 3 2.24721
DENND2D DENN/MADD domain containing 2D 2.24682
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.21233
PDIA5 protein disulfide isomerase family A, member 5 2.19206
CDK7 cyclin-dependent kinase 7 2.09458
TBC1D16 TBC1 domain family, member 16 2.09008
NOSIP nitric oxide synthase interacting protein 2.07273
RNMT RNA (guanine-7-) methyltransferase 2.0484
NCAPD3 non-SMC condensin II complex, subunit D3 2.03499
COMP cartilage oligomeric matrix protein 2.02132

decreased expression

Symbol Name Standardized Value
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -5.33007
PCCB propionyl CoA carboxylase, beta polypeptide -5.00859
KRT14 keratin 14, type I -4.63339
CCNB1 cyclin B1 -4.46791
ETFB electron-transfer-flavoprotein, beta polypeptide -4.42673
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.22246
UFM1 ubiquitin-fold modifier 1 -3.95102
S100A8 S100 calcium binding protein A8 -3.87825
NRIP1 nuclear receptor interacting protein 1 -3.46192
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.91469
ANKRA2 ankyrin repeat, family A (RFXANK-like), 2 -2.73044
REEP5 receptor accessory protein 5 -2.50336
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.4675
GPR18 G protein-coupled receptor 18 -2.44008
SGK1 serum/glucocorticoid regulated kinase 1 -2.41655
CORO1A coronin, actin binding protein, 1A -2.36745
MUL1 mitochondrial E3 ubiquitin protein ligase 1 -2.35959
CATSPERZ catsper channel auxiliary subunit zeta -2.31465
VPS52 vacuolar protein sorting 52 homolog (S. cerevisiae) -2.29692
HMOX2 heme oxygenase 2 -2.27002
TOX3 TOX high mobility group box family member 3 -2.25011
TULP1 tubby like protein 1 -2.23081
REXO2 RNA exonuclease 2 -2.20499
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled -2.19622
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.1864
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) -2.18305
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 -2.16383
AKAP6 A kinase (PRKA) anchor protein 6 -2.15811
PRCP prolylcarboxypeptidase (angiotensinase C) -2.12019
ODF1 outer dense fiber of sperm tails 1 -2.11772
CDC20 cell division cycle 20 -2.11198
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.09974
CTNNA3 catenin (cadherin-associated protein), alpha 3 -2.08183
IRGC immunity-related GTPase family, cinema -2.0817
FAM110A family with sequence similarity 110, member A -2.07123
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) -2.06706
CDC37 cell division cycle 37 -2.06245
LMTK2 lemur tyrosine kinase 2 -2.06211
PRMT8 protein arginine methyltransferase 8 -2.05685
E4F1 E4F transcription factor 1 -2.03731
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3 -2.03656
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4 -2.03004
ZNF764 zinc finger protein 764 -2.02525
NAIP NLR family, apoptosis inhibitory protein -2.01654
ATPAF2 ATP synthase mitochondrial F1 complex assembly factor 2 -2.01346
ACR acrosin -2.01175
RPGRIP1 retinitis pigmentosa GTPase regulator interacting protein 1 -2.00925