CRCGN016_MCF10A.WT.HP_24H:M22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimetridazole 98.38 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

50 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:M22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 4.66105
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.53478
E2F2 E2F transcription factor 2 4.50862
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.48097
COMP cartilage oligomeric matrix protein 3.47906
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.84604
ZNF556 zinc finger protein 556 2.4917
MTTP microsomal triglyceride transfer protein 2.3856
HBB hemoglobin, beta 2.34389
NEK7 NIMA-related kinase 7 2.27438
SPAG4 sperm associated antigen 4 2.273
PECR peroxisomal trans-2-enoyl-CoA reductase 2.25515
DHRS7B dehydrogenase/reductase (SDR family) member 7B 2.23378
CCL16 chemokine (C-C motif) ligand 16 2.18336
MAGT1 magnesium transporter 1 2.13378
ZFHX3 zinc finger homeobox 3 2.12943
NKX2-1 NK2 homeobox 1 2.12698
ZBTB35 zinc finger and BTB domain containing 35 2.11805
FCHO1 FCH domain only 1 2.11345
TCEAL4 transcription elongation factor A (SII)-like 4 2.08555
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 2.06335
CINP cyclin-dependent kinase 2 interacting protein 2.04654
GSTO1 glutathione S-transferase omega 1 2.0328
SNRPG small nuclear ribonucleoprotein polypeptide G 2.01659
GADD45G growth arrest and DNA-damage-inducible, gamma 2.01006
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.00071

decreased expression

Symbol Name Standardized Value
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase -5.11327
SGK1 serum/glucocorticoid regulated kinase 1 -4.78564
OXA1L oxidase (cytochrome c) assembly 1-like -4.70785
LDHD lactate dehydrogenase D -4.46406
C2CD5 C2 calcium-dependent domain containing 5 -3.41906
THAP11 THAP domain containing 11 -3.41719
FOS FBJ murine osteosarcoma viral oncogene homolog -3.33909
CHMP4B charged multivesicular body protein 4B -3.32776
ACO2 aconitase 2, mitochondrial -2.66486
RHOT2 ras homolog family member T2 -2.65572
RBM15B RNA binding motif protein 15B -2.57986
NGRN neugrin, neurite outgrowth associated -2.56951
METTL17 methyltransferase like 17 -2.43331
EIF3G eukaryotic translation initiation factor 3, subunit G -2.41299
ANKMY2 ankyrin repeat and MYND domain containing 2 -2.34668
COG5 component of oligomeric golgi complex 5 -2.34574
S100A8 S100 calcium binding protein A8 -2.28629
CBX7 chromobox homolog 7 -2.18446
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) -2.15628
SDR39U1 short chain dehydrogenase/reductase family 39U, member 1 -2.15412
TWIST1 twist family bHLH transcription factor 1 -2.1493
NAMPT nicotinamide phosphoribosyltransferase -2.10696
PHC1 polyhomeotic homolog 1 (Drosophila) -2.0721
PCSK7 proprotein convertase subtilisin/kexin type 7 -2.04304