CRCGN016_MCF10A.WT.HP_24H:M23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dimetridazole 32.79 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:M23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TBX2 T-box 2 6.29313
ABHD6 abhydrolase domain containing 6 4.71066
ABHD4 abhydrolase domain containing 4 4.65461
CXCR4 chemokine (C-X-C motif) receptor 4 4.63481
AMDHD2 amidohydrolase domain containing 2 4.58644
HBA1 hemoglobin, alpha 1 4.58015
MAP7 microtubule-associated protein 7 4.18617
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.07036
RTN2 reticulon 2 3.80113
HBB hemoglobin, beta 2.80985
GRB10 growth factor receptor-bound protein 10 2.79767
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.76782
LAMC3 laminin, gamma 3 2.71409
SQOR sulfide quinone oxidoreductase 2.66388
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.62858
TRIM13 tripartite motif containing 13 2.46292
RBBP5 retinoblastoma binding protein 5 2.45764
CGRRF1 cell growth regulator with ring finger domain 1 2.36438
COX17 COX17 cytochrome c oxidase copper chaperone 2.16386
LDAF1 lipid droplet assembly factor 1 2.11923
CDT1 chromatin licensing and DNA replication factor 1 2.11902
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.06597
SHMT1 serine hydroxymethyltransferase 1 (soluble) 2.06161
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 2.05264
BCAS4 breast carcinoma amplified sequence 4 2.04598
CASKIN2 CASK interacting protein 2 2.01954
DNASE1L3 deoxyribonuclease I-like 3 2.00335

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -4.23908
DNM1L dynamin 1-like -3.97372
HEATR1 HEAT repeat containing 1 -3.42765
GDF15 growth differentiation factor 15 -2.92843
PSIP1 PC4 and SFRS1 interacting protein 1 -2.72048
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.599
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.59846
TRAP1 TNF receptor-associated protein 1 -2.42214
TRIP12 thyroid hormone receptor interactor 12 -2.39115
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -2.29418
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -2.25242
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -2.10066
PARK7 parkinson protein 7 -2.06719