CRCGN016_MCF10A.WT.HP_24H:N01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzene 98.3 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:N01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADGRE5 adhesion G protein-coupled receptor E5 4.51909
TBPL1 TBP-like 1 3.59668
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 3.37277
CXCR4 chemokine (C-X-C motif) receptor 4 3.23794
CHN1 chimerin 1 2.72581
OLFM1 olfactomedin 1 2.51742
COQ8A coenzyme Q8A 2.39751
TENT4A terminal nucleotidyltransferase 4A 2.39483
C5 complement component 5 2.38654
MAGEA8 melanoma antigen family A8 2.20272
HYOU1 hypoxia up-regulated 1 2.15195
SPRED2 sprouty-related, EVH1 domain containing 2 2.14013
MMP2 matrix metallopeptidase 2 2.13596
RBPJL recombination signal binding protein for immunoglobulin kappa J region-like 2.12792
PTPRK protein tyrosine phosphatase, receptor type, K 2.12714
CDK3 cyclin-dependent kinase 3 2.09327
BMP4 bone morphogenetic protein 4 2.07626
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) 2.07399
ZNF154 zinc finger protein 154 2.02734
LRRC2 leucine rich repeat containing 2 2.01966
RPRM reprimo, TP53 dependent G2 arrest mediator candidate 2.01824
POPDC2 popeye domain containing 2 2.00507

decreased expression

Symbol Name Standardized Value
DYNLT3 dynein, light chain, Tctex-type 3 -5.82661
COG2 component of oligomeric golgi complex 2 -4.88633
HACD3 3-hydroxyacyl-CoA dehydratase 3 -4.69276
PMM2 phosphomannomutase 2 -4.40681
LAP3 leucine aminopeptidase 3 -4.23055
CAB39 calcium binding protein 39 -3.35396
REEP5 receptor accessory protein 5 -3.0265
ARID4B AT rich interactive domain 4B (RBP1-like) -2.80801
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.77726
MSMO1 methylsterol monooxygenase 1 -2.73045
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.47345
ALDOC aldolase C, fructose-bisphosphate -2.40155
MTERF3 mitochondrial transcription termination factor 3 -2.27922
TLCD3A TLC domain containing 3A -2.19821
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.193
SYNGR3 synaptogyrin 3 -2.15575
QDPR quinoid dihydropteridine reductase -2.08955
TSLIG3A tRNA splicing ligase complex subunit 3A -2.08149