CRCGN016_MCF10A.WT.HP_24H:N02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description benzene 32.77 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:N02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 5.55816
HMOX1 heme oxygenase 1 5.12635
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.04165
TBX2 T-box 2 3.86569
MTA2 metastasis associated 1 family, member 2 3.36802
C5 complement component 5 3.33932
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 3.16787
NR1H2 nuclear receptor subfamily 1, group H, member 2 3.12832
LGMN legumain 2.89876
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.72162
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.67891
ZNF35 zinc finger protein 35 2.65514
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.59081
LYN LYN proto-oncogene, Src family tyrosine kinase 2.51476
ISYNA1 inositol-3-phosphate synthase 1 2.47196
RLBP1 retinaldehyde binding protein 1 2.41435
FRS2 fibroblast growth factor receptor substrate 2 2.38404
KLHL11 kelch-like family member 11 2.37559
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.34937
ZNF124 zinc finger protein 124 2.33302
ANKRD44 ankyrin repeat domain 44 2.31356
ZNF221 zinc finger protein 221 2.31355
FAM76A family with sequence similarity 76, member A 2.30507
MEGF8 multiple EGF-like-domains 8 2.26519
THSD4 thrombospondin, type I, domain containing 4 2.25802
CNPY3 canopy FGF signaling regulator 3 2.25399
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.24021
KCNA1 potassium channel, voltage gated shaker related subfamily A, member 1 2.23881
NCR3 natural cytotoxicity triggering receptor 3 2.22474
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.22309
FABP6 fatty acid binding protein 6, ileal 2.2228
PRR7 proline rich 7 (synaptic) 2.20919
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.20622
STK17B serine/threonine kinase 17b 2.20006
PMFBP1 polyamine modulated factor 1 binding protein 1 2.18158
SCN2A sodium channel, voltage gated, type II alpha subunit 2.17442
PDE6B phosphodiesterase 6B, cGMP-specific, rod, beta 2.16711
CCDC33 coiled-coil domain containing 33 2.16282
LPAR3 lysophosphatidic acid receptor 3 2.14998
TLR6 toll-like receptor 6 2.14144
MDM4 MDM4, p53 regulator 2.13883
IPO13 importin 13 2.13509
SPTB spectrin, beta, erythrocytic 2.13393
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.12984
MRLN myoregulin 2.12752
TRIM46 tripartite motif containing 46 2.11949
MOCS3 molybdenum cofactor synthesis 3 2.1038
NRSN2 neurensin 2 2.10287
RBBP5 retinoblastoma binding protein 5 2.10118
RYR3 ryanodine receptor 3 2.0994
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 2.09681
ERN1 endoplasmic reticulum to nucleus signaling 1 2.09478
ZNF467 zinc finger protein 467 2.08777
TRIM39-RPP21 TRIM39-RPP21 readthrough 2.08225
AGO1 argonaute RISC catalytic component 1 2.06976
IL7 interleukin 7 2.06342
GPR4 G protein-coupled receptor 4 2.05992
BMP4 bone morphogenetic protein 4 2.05633
FPR3 formyl peptide receptor 3 2.04874
PCDH12 protocadherin 12 2.04079
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 2.03977
RAMP2 receptor (G protein-coupled) activity modifying protein 2 2.03296
YPEL1 yippee-like 1 (Drosophila) 2.03082
DSTYK dual serine/threonine and tyrosine protein kinase 2.03051
VWA1 von Willebrand factor A domain containing 1 2.02627
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1 2.02496
ACVR2B activin A receptor, type IIB 2.01968
TTYH1 tweety family member 1 2.01439
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.01186
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 2.01077
FOXH1 forkhead box H1 2.00513
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 2.00262
TENT5C terminal nucleotidyltransferase 5C 2.00084

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -8.34378
KIF14 kinesin family member 14 -5.66348
TNIP1 TNFAIP3 interacting protein 1 -5.40027
HACD3 3-hydroxyacyl-CoA dehydratase 3 -5.18003
UFM1 ubiquitin-fold modifier 1 -4.7208
HMG20B high mobility group 20B -4.70678
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.38438
BID BH3 interacting domain death agonist -4.1653
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.95047
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.88902
TSPAN3 tetraspanin 3 -2.83243
MSMO1 methylsterol monooxygenase 1 -2.69851
ARHGAP12 Rho GTPase activating protein 12 -2.5338
MT1X metallothionein 1X -2.45466
EXOSC8 exosome component 8 -2.27625
SAA2 serum amyloid A2 -2.25257
PRDX1 peroxiredoxin 1 -2.16698
SUPT20H suppressor of Ty 20 homolog (S. cerevisiae) -2.15512
TMSB4X thymosin beta 4, X-linked -2.11158
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 -2.0855
ITPRID2 ITPR interacting domain containing 2 -2.06943
COBL cordon-bleu WH2 repeat protein -2.06261
NUP58 nucleoporin 58 -2.02569
LSG1 large 60S subunit nuclear export GTPase 1 -2.01124
ALDH18A1 aldehyde dehydrogenase 18 family, member A1 -2.01003