CRCGN016_MCF10A.WT.HP_24H:N07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrofural 97.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

59 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:N07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 5.26746
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.96499
GLOD4 glyoxalase domain containing 4 4.6781
KLHL21 kelch-like family member 21 4.49388
PPP1R13B protein phosphatase 1, regulatory subunit 13B 4.36559
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 4.26409
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 3.85607
ANO10 anoctamin 10 3.60612
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.70788
NRBF2 nuclear receptor binding factor 2 2.6347
PEX12 peroxisomal biogenesis factor 12 2.47609
ACAA1 acetyl-CoA acyltransferase 1 2.47117
BAG5 BCL2-associated athanogene 5 2.46218
GLRX5 glutaredoxin 5 2.43749
ZNF443 zinc finger protein 443 2.41349
LGMN legumain 2.41248
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 2.36428
GASK1B golgi associated kinase 1B 2.23675
NXPE3 neurexophilin and PC-esterase domain family, member 3 2.20826
SFRP4 secreted frizzled-related protein 4 2.20802
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.17757
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 2.15919
ATP5MJ ATP synthase membrane subunit j 2.15128
THAP1 THAP domain containing, apoptosis associated protein 1 2.1506
TGFBR3 transforming growth factor, beta receptor III 2.142
APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 2.11139
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) 2.10195
COL9A3 collagen, type IX, alpha 3 2.09427
ZEB2 zinc finger E-box binding homeobox 2 2.06256
LEFTY1 left-right determination factor 1 2.04249
SLC25A38 solute carrier family 25, member 38 2.02061
PIGK phosphatidylinositol glycan anchor biosynthesis, class K 2.00961

decreased expression

Symbol Name Standardized Value
KIF20A kinesin family member 20A -8.14403
BASP1 brain abundant, membrane attached signal protein 1 -5.90058
YME1L1 YME1-like 1 ATPase -4.72267
CDC45 cell division cycle 45 -4.61088
DERA deoxyribose-phosphate aldolase (putative) -4.41011
BAG3 BCL2-associated athanogene 3 -4.15681
TRAPPC3 trafficking protein particle complex 3 -3.77337
SCYL3 SCY1-like 3 (S. cerevisiae) -3.50919
CAB39 calcium binding protein 39 -3.40946
MBOAT7 membrane bound O-acyltransferase domain containing 7 -3.35501
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.8526
CDC25C cell division cycle 25C -2.74974
TENT4A terminal nucleotidyltransferase 4A -2.71286
UFD1 ubiquitin recognition factor in ER associated degradation 1 -2.41185
TDP2 tyrosyl-DNA phosphodiesterase 2 -2.34926
TEAD3 TEA domain family member 3 -2.34698
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -2.31601
ARID4B AT rich interactive domain 4B (RBP1-like) -2.3093
ABI1 abl-interactor 1 -2.28268
HARS1 histidyl-tRNA synthetase 1 -2.26005
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.24288
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.21112
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.20019
AADAC arylacetamide deacetylase -2.19514
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.13934
RNF11 ring finger protein 11 -2.06175
RAB13 RAB13, member RAS oncogene family -2.05057