CRCGN016_MCF10A.WT.HP_24H:N09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description nitrofural 10.87 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

68 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:N09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CIAO3 cytosolic iron-sulfur assembly component 3 4.4289
SPAG4 sperm associated antigen 4 3.94127
COMP cartilage oligomeric matrix protein 3.76229
ECH1 enoyl CoA hydratase 1, peroxisomal 3.22008
PRKCQ protein kinase C, theta 3.03262
AXIN1 axin 1 2.99874
MAST2 microtubule associated serine/threonine kinase 2 2.90081
SNAP25 synaptosomal-associated protein, 25kDa 2.83149
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.82366
STX4 syntaxin 4 2.64048
BICD1 bicaudal D homolog 1 (Drosophila) 2.54422
KDM5A lysine (K)-specific demethylase 5A 2.48049
SLC28A3 solute carrier family 28 (concentrative nucleoside transporter), member 3 2.46493
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.38463
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.37872
TBX2 T-box 2 2.36433
SP4 Sp4 transcription factor 2.35449
PRODH2 proline dehydrogenase (oxidase) 2 2.30039
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.29666
SLC6A5 solute carrier family 6 (neurotransmitter transporter), member 5 2.26823
ST7L suppression of tumorigenicity 7 like 2.26136
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 2.22909
CRMP1 collapsin response mediator protein 1 2.1881
SAMD4B sterile alpha motif domain containing 4B 2.18481
KREMEN2 kringle containing transmembrane protein 2 2.17707
CNPY3 canopy FGF signaling regulator 3 2.17119
NEUROG1 neurogenin 1 2.1421
CD200 CD200 molecule 2.13713
FRMD1 FERM domain containing 1 2.13688
TRAIP TRAF interacting protein 2.12766
RAD54L RAD54-like (S. cerevisiae) 2.11412
OVOL1 ovo-like zinc finger 1 2.11098
SCG3 secretogranin III 2.09271
ZNF550 zinc finger protein 550 2.08867
AHDC1 AT hook, DNA binding motif, containing 1 2.08658
NLGN4Y neuroligin 4, Y-linked 2.07454
BCL2L14 BCL2-like 14 (apoptosis facilitator) 2.06109
AP1B1 adaptor-related protein complex 1, beta 1 subunit 2.05989
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 2.05356
CCDC91 coiled-coil domain containing 91 2.05195
MYOZ3 myozenin 3 2.05153
COLQ collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase 2.05151
CACNB1 calcium channel, voltage-dependent, beta 1 subunit 2.05098
RGS7 regulator of G-protein signaling 7 2.04626
NALF2 NALCN channel auxiliary factor 2 2.04343
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.02954
TM7SF3 transmembrane 7 superfamily member 3 2.02122
LSG1 large 60S subunit nuclear export GTPase 1 2.01944
SYN1 synapsin I 2.00767

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -6.78257
GDF15 growth differentiation factor 15 -5.85296
CDC25B cell division cycle 25B -4.02458
TXNDC9 thioredoxin domain containing 9 -3.92323
CCNB1 cyclin B1 -3.91902
CHIC2 cysteine-rich hydrophobic domain 2 -3.68036
UFM1 ubiquitin-fold modifier 1 -3.55843
BASP1 brain abundant, membrane attached signal protein 1 -3.22219
BAG3 BCL2-associated athanogene 3 -3.03889
CANT1 calcium activated nucleotidase 1 -2.99539
MELK maternal embryonic leucine zipper kinase -2.78442
RBM15B RNA binding motif protein 15B -2.71703
MCOLN1 mucolipin 1 -2.38064
ZFYVE16 zinc finger, FYVE domain containing 16 -2.2841
JPT1 Jupiter microtubule associated homolog 1 -2.25267
NUP85 nucleoporin 85kDa -2.22913
MYO5A myosin VA (heavy chain 12, myoxin) -2.20323
NCOA6 nuclear receptor coactivator 6 -2.02767
RPS5 ribosomal protein S5 -2.00944