CRCGN016_MCF10A.WT.HP_24H:N16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description vinylidene chloride 105.29 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:N16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CASP2 caspase 2, apoptosis-related cysteine peptidase 5.26986
TBX2 T-box 2 4.515
HBA1 hemoglobin, alpha 1 4.48278
ACAA1 acetyl-CoA acyltransferase 1 4.22476
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 3.94803
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 3.87425
OLFML2B olfactomedin-like 2B 3.11023
YEATS2 YEATS domain containing 2 2.41837
MTA2 metastasis associated 1 family, member 2 2.39039
DNASE1L3 deoxyribonuclease I-like 3 2.3703
AGR2 anterior gradient 2 2.27788
HNRNPL heterogeneous nuclear ribonucleoprotein L 2.26682
LY75-CD302 LY75-CD302 readthrough 2.23151
PRL prolactin 2.1565
STAT2 signal transducer and activator of transcription 2, 113kDa 2.13659
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 2.128
CCDC91 coiled-coil domain containing 91 2.1242
YAF2 YY1 associated factor 2 2.1209
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.07755
RFWD3 ring finger and WD repeat domain 3 2.06914
IRAK4 interleukin-1 receptor-associated kinase 4 2.05965
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 2.05667
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 2.05192
OSTF1 osteoclast stimulating factor 1 2.04332
PLEKHA2 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 2.04291
MAN1C1 mannosidase, alpha, class 1C, member 1 2.03758
RNF125 ring finger protein 125, E3 ubiquitin protein ligase 2.0336
WDR76 WD repeat domain 76 2.01639
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.01615
ZNF451 zinc finger protein 451 2.0084
STAMBP STAM binding protein 2.0017

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -5.19895
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.45596
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.75906
PCCB propionyl CoA carboxylase, beta polypeptide -3.5567
GDF15 growth differentiation factor 15 -3.41341
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.20685
CANT1 calcium activated nucleotidase 1 -3.01107
HTRA1 HtrA serine peptidase 1 -2.55774
TMEM115 transmembrane protein 115 -2.46027
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.21615
IFRD2 interferon-related developmental regulator 2 -2.20664
MUC6 mucin 6, oligomeric mucus/gel-forming -2.11014
FLRT2 fibronectin leucine rich transmembrane protein 2 -2.10712
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.07711