CRCGN016_MCF10A.WT.HP_24H:N21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description fenthion 11.74 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:N21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 4.366
C2CD2 C2 calcium-dependent domain containing 2 4.26238
DENND2D DENN/MADD domain containing 2D 3.86929
NOTCH1 notch 1 3.63869
RSF1 remodeling and spacing factor 1 3.18519
BMP4 bone morphogenetic protein 4 2.94221
SATB1 SATB homeobox 1 2.55322
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.50871
COMP cartilage oligomeric matrix protein 2.48871
OLFML2B olfactomedin-like 2B 2.47247
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 2.40178
MMP1 matrix metallopeptidase 1 2.39798
ALG8 ALG8, alpha-1,3-glucosyltransferase 2.36774
NELL2 NEL-like 2 (chicken) 2.36116
UVRAG UV radiation resistance associated 2.3072
PKN1 protein kinase N1 2.29451
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.08101

decreased expression

Symbol Name Standardized Value
CCNB2 cyclin B2 -4.36714
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -4.33955
HMG20B high mobility group 20B -4.26206
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -4.10645
GDF15 growth differentiation factor 15 -3.58451
VDAC1 voltage-dependent anion channel 1 -3.23391
EXOSC4 exosome component 4 -3.18898
SGK1 serum/glucocorticoid regulated kinase 1 -2.93503
TLCD3A TLC domain containing 3A -2.93146
PRCP prolylcarboxypeptidase (angiotensinase C) -2.7166
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.47827
MT1X metallothionein 1X -2.38914
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.27916
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -2.26817
FABP5 fatty acid binding protein 5 (psoriasis-associated) -2.12822
TRIM9 tripartite motif containing 9 -2.0971
SHPK sedoheptulokinase -2.0002