CRCGN016_MCF10A.WT.HP_24H:N22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description medroxyprogesterone 99.12 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:N22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 3.47011
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.40566
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 3.1882
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.15246
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.86745
TBX2 T-box 2 2.86666
GATA3 GATA binding protein 3 2.81207
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.81181
FHL2 four and a half LIM domains 2 2.80453
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.79711
TRIB3 tribbles pseudokinase 3 2.70982
AGR2 anterior gradient 2 2.69936
LRP10 low density lipoprotein receptor-related protein 10 2.66904
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.66845
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.65915
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.59137
PKN1 protein kinase N1 2.43158
INSIG1 insulin induced gene 1 2.41996
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.41324
SQOR sulfide quinone oxidoreductase 2.41208
COPB1 coatomer protein complex, subunit beta 1 2.35288
FHOD1 formin homology 2 domain containing 1 2.33662
COMP cartilage oligomeric matrix protein 2.24518
RIC8A RIC8 guanine nucleotide exchange factor A 2.21778
TMEM41B transmembrane protein 41B 2.2119
AAMDC adipogenesis associated, Mth938 domain containing 2.12724
DEF6 differentially expressed in FDCP 6 homolog (mouse) 2.1184
EMSY EMSY transcriptional repressor, BRCA2 interacting 2.1029
CALU calumenin 2.10044
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.10015
SREK1IP1 SREK1-interacting protein 1 2.09921
FKBP14 FK506 binding protein 14, 22 kDa 2.08881
SOAT2 sterol O-acyltransferase 2 2.08682
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 2.07071
HMGA2 high mobility group AT-hook 2 2.06808
GLRX glutaredoxin (thioltransferase) 2.05073
NIPSNAP1 nipsnap homolog 1 (C. elegans) 2.0468
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 2.00922
UVRAG UV radiation resistance associated 2.00752

decreased expression

Symbol Name Standardized Value
CD320 CD320 molecule -5.35621
CDC45 cell division cycle 45 -4.90188
RPIA ribose 5-phosphate isomerase A -4.51881
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.95094
ADRB2 adrenoceptor beta 2, surface -3.79433
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.3125
ATF5 activating transcription factor 5 -3.06725
ARID4B AT rich interactive domain 4B (RBP1-like) -2.62857
PRR15L proline rich 15-like -2.533
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.46725
CYCS cytochrome c, somatic -2.46015
VDAC1 voltage-dependent anion channel 1 -2.45205
CHMP4B charged multivesicular body protein 4B -2.33617
FASTKD5 FAST kinase domains 5 -2.26003
NFIL3 nuclear factor, interleukin 3 regulated -2.22851
CDK4 cyclin-dependent kinase 4 -2.20602
TIMM44 translocase of inner mitochondrial membrane 44 homolog (yeast) -2.12983
CCDC86 coiled-coil domain containing 86 -2.12807
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.0913
TMEM50A transmembrane protein 50A -2.08141
SETMAR SET domain and mariner transposase fusion gene -2.04819
NUP133 nucleoporin 133kDa -2.04545
RPP40 ribonuclease P/MRP 40kDa subunit -2.04296
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.0346
TATDN2 TatD DNase domain containing 2 -2.0311
CREG1 cellular repressor of E1A-stimulated genes 1 -2.02772
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.0221
NLRP2B NLR family pyrin domain containing 2B -2.01811
GLOD4 glyoxalase domain containing 4 -2.01454
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.01265
URB2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) -2.00267