CRCGN016_MCF10A.WT.HP_24H:N23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description medroxyprogesterone 33.04 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

37 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:N23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.50162
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 4.11594
EPHB2 EPH receptor B2 3.38757
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.87422
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.69949
ADGRG1 adhesion G protein-coupled receptor G1 2.69253
GNB5 guanine nucleotide binding protein (G protein), beta 5 2.55094
CCL2 chemokine (C-C motif) ligand 2 2.52341
SIRT6 sirtuin 6 2.51463
SNX11 sorting nexin 11 2.46157
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.4489
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.2714
IRF2BP1 interferon regulatory factor 2 binding protein 1 2.23003
ELOVL6 ELOVL fatty acid elongase 6 2.19767
SPAG4 sperm associated antigen 4 2.18147
FHL2 four and a half LIM domains 2 2.14945
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.10742
HHLA1 HERV-H LTR-associating 1 2.0908
ALAS1 5'-aminolevulinate synthase 1 2.08471
USP5 ubiquitin specific peptidase 5 (isopeptidase T) 2.02252
MED15 mediator complex subunit 15 2.01719
MOSPD3 motile sperm domain containing 3 2.01549
TFEB transcription factor EB 2.00063

decreased expression

Symbol Name Standardized Value
TSPAN4 tetraspanin 4 -5.19662
TM9SF3 transmembrane 9 superfamily member 3 -4.82487
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.75564
ACAA1 acetyl-CoA acyltransferase 1 -2.68332
STMN1 stathmin 1 -2.34272
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.25135
DUSP14 dual specificity phosphatase 14 -2.21096
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.18798
STK26 serine/threonine protein kinase 26 -2.18047
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma -2.17794
ARID4B AT rich interactive domain 4B (RBP1-like) -2.14043
GSTZ1 glutathione S-transferase zeta 1 -2.13965
RGS2 regulator of G-protein signaling 2 -2.10576
OXSR1 oxidative stress responsive 1 -2.00073