CRCGN016_MCF10A.WT.HP_24H:N24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description medroxyprogesterone 11.01 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:N24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 9.08475
CCDC92 coiled-coil domain containing 92 4.21747
KLHL21 kelch-like family member 21 3.65148
C2CD2 C2 calcium-dependent domain containing 2 3.54468
KCTD5 potassium channel tetramerization domain containing 5 3.30314
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.21589
EPHB2 EPH receptor B2 2.81783
HDGFL3 HDGF like 3 2.65444
NSDHL NAD(P) dependent steroid dehydrogenase-like 2.56194
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 2.52305
FHL2 four and a half LIM domains 2 2.45632
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.36713
MELK maternal embryonic leucine zipper kinase 2.07746
HSPA1A heat shock 70kDa protein 1A 2.07441
SOAT2 sterol O-acyltransferase 2 2.06729
PITPNB phosphatidylinositol transfer protein, beta 2.03069
CCNF cyclin F 2.02994
ELOVL6 ELOVL fatty acid elongase 6 2.01168

decreased expression

Symbol Name Standardized Value
PCCB propionyl CoA carboxylase, beta polypeptide -6.62613
ALAS1 5'-aminolevulinate synthase 1 -3.5406
VAT1 vesicle amine transport 1 -3.41865
CCDC86 coiled-coil domain containing 86 -3.1941
RNF167 ring finger protein 167 -3.11712
GTPBP8 GTP-binding protein 8 (putative) -3.10714
NGRN neugrin, neurite outgrowth associated -2.7329
C1QBP complement component 1, q subcomponent binding protein -2.69241
SGK1 serum/glucocorticoid regulated kinase 1 -2.55515
PTK2 protein tyrosine kinase 2 -2.39804
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.15377
RGS2 regulator of G-protein signaling 2 -2.13862
NISCH nischarin -2.07852
NCAPD2 non-SMC condensin I complex, subunit D2 -2.04949