CRCGN016_MCF10A.WT.HP_24H:O01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.36304
CGRRF1 cell growth regulator with ring finger domain 1 3.93367
MOK MOK protein kinase 3.86523
MYLK myosin light chain kinase 3.63448
INTS3 integrator complex subunit 3 3.55725
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 3.35951
MEF2C myocyte enhancer factor 2C 3.29538
TBPL1 TBP-like 1 3.19983
HBA1 hemoglobin, alpha 1 2.81166
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 2.5412
TBC1D10C TBC1 domain family, member 10C 2.50107
DNAAF2 dynein, axonemal, assembly factor 2 2.49328
TXNDC9 thioredoxin domain containing 9 2.44708
PDIA5 protein disulfide isomerase family A, member 5 2.4257
CAMKMT calmodulin-lysine N-methyltransferase 2.39982
LYRM1 LYR motif containing 1 2.37727
TEX10 testis expressed 10 2.3427
SMAD3 SMAD family member 3 2.34266
TLCD3A TLC domain containing 3A 2.33746
WDHD1 WD repeat and HMG-box DNA binding protein 1 2.31116
SIAH1 siah E3 ubiquitin protein ligase 1 2.29545
TMEM9B TMEM9 domain family, member B 2.26911
TEFM transcription elongation factor, mitochondrial 2.24471
SCRG1 stimulator of chondrogenesis 1 2.24212
TIPIN TIMELESS interacting protein 2.23091
ADRB2 adrenoceptor beta 2, surface 2.22862
RPP30 ribonuclease P/MRP 30kDa subunit 2.22007
THADA thyroid adenoma associated 2.18742
TMEM11 transmembrane protein 11 2.17981
NUP54 nucleoporin 54kDa 2.14868
DBF4 DBF4 zinc finger 2.13471
TLE3 transducin-like enhancer of split 3 2.09565
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.04966
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.04339
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha 2.04191
P2RX7 purinergic receptor P2X, ligand gated ion channel, 7 2.03773
CRIPT cysteine-rich PDZ-binding protein 2.02664
POLR1G RNA polymerase I subunit G 2.01249
LIMD1 LIM domains containing 1 2.01002

decreased expression

Symbol Name Standardized Value
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.04399
DNM1L dynamin 1-like -3.77743
BASP1 brain abundant, membrane attached signal protein 1 -3.71251
TIMP1 TIMP metallopeptidase inhibitor 1 -3.42178
ARID4B AT rich interactive domain 4B (RBP1-like) -3.37497
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.10779
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.06925
TRAP1 TNF receptor-associated protein 1 -2.9292
KLHL3 kelch-like family member 3 -2.84806
CAPRIN2 caprin family member 2 -2.76561
ESYT1 extended synaptotagmin-like protein 1 -2.74206
TMEM109 transmembrane protein 109 -2.65371
PIGG phosphatidylinositol glycan anchor biosynthesis, class G -2.60885
CD81 CD81 molecule -2.60528
COG7 component of oligomeric golgi complex 7 -2.58361
DPP3 dipeptidyl-peptidase 3 -2.55174
SLC75A1 solute carrier family 75 member 1 -2.53387
S100A8 S100 calcium binding protein A8 -2.51833
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) -2.28458
SEMA3G sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G -2.23715
IL2RG interleukin 2 receptor, gamma -2.22288
ASB8 ankyrin repeat and SOCS box containing 8 -2.17076
TUBB6 tubulin, beta 6 class V -2.14248
SOD1 superoxide dismutase 1, soluble -2.08579
FKBP9 FK506 binding protein 9, 63 kDa -2.06693
ERGIC2 ERGIC and golgi 2 -2.03569
KLF7 Kruppel-like factor 7 (ubiquitous) -2.01068