CRCGN016_MCF10A.WT.HP_24H:O02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TBX2 T-box 2 6.33448
TSEN2 TSEN2 tRNA splicing endonuclease subunit 5.34815
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.64498
CGRRF1 cell growth regulator with ring finger domain 1 4.18319
AMDHD2 amidohydrolase domain containing 2 3.10722
RAB11FIP2 RAB11 family interacting protein 2 (class I) 3.01837
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.93884
PHOX2A paired-like homeobox 2a 2.82788
SSBP2 single-stranded DNA binding protein 2 2.80719
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.7443
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 2.73423
NRBF2 nuclear receptor binding factor 2 2.66037
MORN1 MORN repeat containing 1 2.50006
CCL13 chemokine (C-C motif) ligand 13 2.4396
DPP6 dipeptidyl-peptidase 6 2.41535
ZNF205 zinc finger protein 205 2.36672
PDCD1 programmed cell death 1 2.30866
HOXA11 homeobox A11 2.29771
PCDHB12 protocadherin beta 12 2.2395
FZD8 frizzled class receptor 8 2.2364
POU3F2 POU class 3 homeobox 2 2.19954
WT1 Wilms tumor 1 2.19595
FAM110A family with sequence similarity 110, member A 2.19054
MCUR1 mitochondrial calcium uniporter regulator 1 2.18748
ADGRB3 adhesion G protein-coupled receptor B3 2.1474
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.14122
DUX4 double homeobox 4 2.13358
EYA4 EYA transcriptional coactivator and phosphatase 4 2.12685
SAMD14 sterile alpha motif domain containing 14 2.12652
PCDHB6 protocadherin beta 6 2.119
GTF2A1 general transcription factor IIA, 1, 19/37kDa 2.11365
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 2.08723
CERS1 ceramide synthase 1 2.08353
ATXN7L1 ataxin 7-like 1 2.08249
TMOD1 tropomodulin 1 2.07832
PDGFRB platelet-derived growth factor receptor, beta polypeptide 2.07715
CHN1 chimerin 1 2.07567
HOMER1 homer scaffolding protein 1 2.06757
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 2.0632
SIKE1 suppressor of IKBKE 1 2.05479
RUVBL1 RuvB-like AAA ATPase 1 2.04994
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2.0479
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.03575
ALG11 ALG11, alpha-1,2-mannosyltransferase 2.03406
PTPN9 protein tyrosine phosphatase, non-receptor type 9 2.02074
ATG12 autophagy related 12 2.0167
SPEG SPEG complex locus 2.01541
GBX1 gastrulation brain homeobox 1 2.01087
LOC102724594 splicing factor U2AF 35 kDa subunit 2.00811
DNAAF8 dynein axonemal assembly factor 8 2.00377

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -6.59493
TARBP1 TAR (HIV-1) RNA binding protein 1 -5.4702
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -5.3514
DSG2 desmoglein 2 -5.34128
TUBB6 tubulin, beta 6 class V -5.09742
HOXA5 homeobox A5 -4.17505
SCYL3 SCY1-like 3 (S. cerevisiae) -3.45713
BASP1 brain abundant, membrane attached signal protein 1 -2.87858
STAT5A signal transducer and activator of transcription 5A -2.26593
CYFIP1 cytoplasmic FMR1 interacting protein 1 -2.22996
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -2.1995
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -2.18275
PON2 paraoxonase 2 -2.1583
PIEZO1 piezo-type mechanosensitive ion channel component 1 -2.08063
ACADVL acyl-CoA dehydrogenase, very long chain -2.05589
RNF220 ring finger protein 220 -2.04445