CRCGN016_MCF10A.WT.HP_24H:O04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description UnTrt perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

58 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TLR4 toll-like receptor 4 5.46152
CCP110 centriolar coiled coil protein 110kDa 3.91414
SNAP25 synaptosomal-associated protein, 25kDa 3.85145
LAGE3 L antigen family, member 3 3.83692
AGR2 anterior gradient 2 3.79735
PPP1R13B protein phosphatase 1, regulatory subunit 13B 3.60263
SDHAF3 succinate dehydrogenase complex assembly factor 3 2.96435
CNRIP1 cannabinoid receptor interacting protein 1 2.93536
NOSIP nitric oxide synthase interacting protein 2.82284
CGRRF1 cell growth regulator with ring finger domain 1 2.69013
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.51952
CALML4 calmodulin-like 4 2.51629
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.50584
CHSY1 chondroitin sulfate synthase 1 2.40261
PARN poly(A)-specific ribonuclease 2.39518
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 2.37461
OLFM1 olfactomedin 1 2.29952
LYSET lysosomal enzyme trafficking factor 2.27455
SYT1 synaptotagmin I 2.26013
TBPL1 TBP-like 1 2.25001
COMMD10 COMM domain containing 10 2.23426
BEX2 brain expressed X-linked 2 2.22754
IFI44L interferon-induced protein 44-like 2.21879
MGST3 microsomal glutathione S-transferase 3 2.20449
ARMCX6 armadillo repeat containing, X-linked 6 2.19149
SLC25A40 solute carrier family 25, member 40 2.16311
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.15323
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 2.08692
STMN2 stathmin 2 2.06564
PELI2 pellino E3 ubiquitin protein ligase family member 2 2.04614

decreased expression

Symbol Name Standardized Value
TES testin LIM domain protein -5.51968
HSPA8 heat shock 70kDa protein 8 -4.60309
S100A8 S100 calcium binding protein A8 -4.02356
DYNLT3 dynein, light chain, Tctex-type 3 -3.69979
SORBS3 sorbin and SH3 domain containing 3 -3.34111
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -3.2879
APEH acylaminoacyl-peptide hydrolase -3.14322
IFRD2 interferon-related developmental regulator 2 -2.71211
TMEM115 transmembrane protein 115 -2.58764
TGM4 transglutaminase 4 -2.51825
STK25 serine/threonine kinase 25 -2.47301
CBR3 carbonyl reductase 3 -2.37075
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.32576
ERBB2 erb-b2 receptor tyrosine kinase 2 -2.31084
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -2.31004
LMF2 lipase maturation factor 2 -2.26793
PPP6R2 protein phosphatase 6, regulatory subunit 2 -2.21939
MN1 meningioma (disrupted in balanced translocation) 1 -2.13857
PSKH1 protein serine kinase H1 -2.12316
RNF123 ring finger protein 123 -2.09681
LYPD3 LY6/PLAUR domain containing 3 -2.0765
MATK megakaryocyte-associated tyrosine kinase -2.06251
DIPK1A divergent protein kinase domain 1A -2.06187
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) -2.05828
TRMT2A tRNA methyltransferase 2 homolog A (S. cerevisiae) -2.04882
KRT14 keratin 14, type I -2.0205
PCSK7 proprotein convertase subtilisin/kexin type 7 -2.01448
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B -2.01235