CRCGN016_MCF10A.WT.HP_24H:O07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description BRD-K61463582 98.45 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

69 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GPER1 G protein-coupled estrogen receptor 1 5.27518
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.1
HBA1 hemoglobin, alpha 1 4.35057
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 4.12208
CDPF1 cysteine-rich, DPF motif domain containing 1 3.79369
VGLL4 vestigial-like family member 4 3.53929
SQOR sulfide quinone oxidoreductase 2.97489
TBX2 T-box 2 2.92989
HBB hemoglobin, beta 2.9177
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.84025
ACSL5 acyl-CoA synthetase long-chain family member 5 2.83696
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.68311
BAX BCL2-associated X protein 2.62256
MAP2K5 mitogen-activated protein kinase kinase 5 2.60239
DDB2 damage-specific DNA binding protein 2, 48kDa 2.54787
RUVBL1 RuvB-like AAA ATPase 1 2.37145
ACAA1 acetyl-CoA acyltransferase 1 2.32938
IL1B interleukin 1, beta 2.32133
TICAM1 toll-like receptor adaptor molecule 1 2.26432
FCHO1 FCH domain only 1 2.26361
HLA-DRA major histocompatibility complex, class II, DR alpha 2.23024
AEN apoptosis enhancing nuclease 2.14986
ENGASE endo-beta-N-acetylglucosaminidase 2.12416
FAIM Fas apoptotic inhibitory molecule 2.08955
ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 2.0484
DKK4 dickkopf WNT signaling pathway inhibitor 4 2.04142
SERF1A small EDRK-rich factor 1A (telomeric) 2.02623
RFXANK regulatory factor X-associated ankyrin-containing protein 2.01174

decreased expression

Symbol Name Standardized Value
SLC35B1 solute carrier family 35, member B1 -5.76105
COG7 component of oligomeric golgi complex 7 -5.66143
GOLT1B golgi transport 1B -5.31941
KIF14 kinesin family member 14 -5.11052
DCK deoxycytidine kinase -4.86542
TIMP1 TIMP metallopeptidase inhibitor 1 -4.5657
TSPAN4 tetraspanin 4 -4.30169
CTNND1 catenin (cadherin-associated protein), delta 1 -4.0774
PSRC1 proline/serine-rich coiled-coil 1 -3.25868
KRT14 keratin 14, type I -3.20488
RXYLT1 ribitol xylosyltransferase 1 -3.19836
RECQL RecQ helicase-like -3.00957
TTK TTK protein kinase -2.99995
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) -2.91291
CLEC7A C-type lectin domain family 7, member A -2.79366
SOCS6 suppressor of cytokine signaling 6 -2.60845
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -2.6042
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.51926
SGK1 serum/glucocorticoid regulated kinase 1 -2.31285
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -2.29082
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.28866
SMCO4 single-pass membrane protein with coiled-coil domains 4 -2.26264
ARMCX5 armadillo repeat containing, X-linked 5 -2.25348
PGM3 phosphoglucomutase 3 -2.23124
INTS13 integrator complex subunit 13 -2.21585
VASH1 vasohibin 1 -2.21027
BMAL2 basic helix-loop-helix ARNT like 2 -2.19465
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa -2.19051
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.16531
NGRN neugrin, neurite outgrowth associated -2.14715
METTL25B methyltransferase like 25B -2.14024
GIMAP4 GTPase, IMAP family member 4 -2.12279
PPP4C protein phosphatase 4, catalytic subunit -2.10199
ORC3 origin recognition complex, subunit 3 -2.0989
RPS5 ribosomal protein S5 -2.09523
PRCP prolylcarboxypeptidase (angiotensinase C) -2.09076
EDIL3 EGF-like repeats and discoidin I-like domains 3 -2.08755
MED21 mediator complex subunit 21 -2.07033
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.03741
ANG angiogenin, ribonuclease, RNase A family, 5 -2.0245
PALB2 partner and localizer of BRCA2 -2.01172