CRCGN016_MCF10A.WT.HP_24H:O10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description estrone 102.15 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 3.18299
HOXA5 homeobox A5 2.53834
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 2.3951
GADD45A growth arrest and DNA-damage-inducible, alpha 2.2638
RPP38 ribonuclease P/MRP 38kDa subunit 2.22961
DENND2D DENN/MADD domain containing 2D 2.1296
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.06526

decreased expression

Symbol Name Standardized Value
MRPS2 mitochondrial ribosomal protein S2 -4.92727
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.19519
JMJD6 jumonji domain containing 6 -3.96882
TLCD3A TLC domain containing 3A -3.86866
PAEP progestagen-associated endometrial protein -2.9117
ERC2 ELKS/RAB6-interacting/CAST family member 2 -2.82953
SEC16A SEC16 homolog A (S. cerevisiae) -2.77171
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.65633
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.56035
PDZD8 PDZ domain containing 8 -2.28381
MSMO1 methylsterol monooxygenase 1 -2.15681
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.08015
PMPCA peptidase (mitochondrial processing) alpha -2.07923
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.05463
CXCL8 chemokine (C-X-C motif) ligand 8 -2.03949
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.03148