CRCGN016_MCF10A.WT.HP_24H:O11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description estrone 34.05 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 4.30922
STK10 serine/threonine kinase 10 4.2024
ADGRE5 adhesion G protein-coupled receptor E5 3.74925
SMIM40 small integral membrane protein 40 3.65646
CHMP6 charged multivesicular body protein 6 2.91122
AGR2 anterior gradient 2 2.81282
THAP11 THAP domain containing 11 2.66989
COMP cartilage oligomeric matrix protein 2.64724
CADM1 cell adhesion molecule 1 2.57918
EPHB2 EPH receptor B2 2.4783
SYNGAP1 synaptic Ras GTPase activating protein 1 2.38883
JADE3 jade family PHD finger 3 2.27578
KAT6B K(lysine) acetyltransferase 6B 2.16225
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.15719
CCP110 centriolar coiled coil protein 110kDa 2.14032
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) 2.11061
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.0941
NDE1 nudE neurodevelopment protein 1 2.03743
SEC24C SEC24 family member C 2.0353
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 2.00612

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -5.48972
TES testin LIM domain protein -3.78849
SGK1 serum/glucocorticoid regulated kinase 1 -3.21499
KRT14 keratin 14, type I -3.16357
CCDC86 coiled-coil domain containing 86 -3.14649
LDHD lactate dehydrogenase D -3.11581
DERA deoxyribose-phosphate aldolase (putative) -3.00542
ENOPH1 enolase-phosphatase 1 -2.92889
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.76928
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.72027
SCYL3 SCY1-like 3 (S. cerevisiae) -2.6404
TXNDC9 thioredoxin domain containing 9 -2.63528
PCNA proliferating cell nuclear antigen -2.56443
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.37601
MELK maternal embryonic leucine zipper kinase -2.28014
C2CD5 C2 calcium-dependent domain containing 5 -2.22372
CLIP1 CAP-GLY domain containing linker protein 1 -2.1897
KRT5 keratin 5, type II -2.07814
KRT16 keratin 16, type I -2.04209