CRCGN016_MCF10A.WT.HP_24H:O12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description estrone 11.35 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADAT1 adenosine deaminase, tRNA-specific 1 4.74379
GARRE1 granule associated Rac and RHOG effector 1 3.82481
FGFR4 fibroblast growth factor receptor 4 3.55445
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.22122
CCP110 centriolar coiled coil protein 110kDa 3.09086
IDE insulin-degrading enzyme 2.81137
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.69945
ALPK1 alpha-kinase 1 2.57307
PHACTR4 phosphatase and actin regulator 4 2.4922
MUC1 mucin 1, cell surface associated 2.42458
ABHD18 abhydrolase domain containing 18 2.36001
VEZT vezatin, adherens junctions transmembrane protein 2.35422
TRAPPC13 trafficking protein particle complex 13 2.35118
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.34233
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough 2.33011
CCL2 chemokine (C-C motif) ligand 2 2.31779
PCDHGA8 protocadherin gamma subfamily A, 8 2.31098
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.30134
COMP cartilage oligomeric matrix protein 2.25189
NUCB2 nucleobindin 2 2.21866
WWC2 WW and C2 domain containing 2 2.18412
ZNF273 zinc finger protein 273 2.16512
STARD5 StAR-related lipid transfer (START) domain containing 5 2.14844
ESRRG estrogen-related receptor gamma 2.13908
CADM1 cell adhesion molecule 1 2.12923
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.11284
CCNA1 cyclin A1 2.10752
THBS2 thrombospondin 2 2.09209
PODNL1 podocan-like 1 2.07971
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.07157
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide 2.06971
RBM41 RNA binding motif protein 41 2.06741
MBOAT2 membrane bound O-acyltransferase domain containing 2 2.06551
ADAP2 ArfGAP with dual PH domains 2 2.05356
H2AZ2 H2A.Z variant histone 2 2.04649
ZNF611 zinc finger protein 611 2.03763
PRR11 proline rich 11 2.03522
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2.03099
MAGT1 magnesium transporter 1 2.02744
XRCC2 X-ray repair complementing defective repair in Chinese hamster cells 2 2.01968
FGG fibrinogen gamma chain 2.01161
KCNK5 potassium channel, two pore domain subfamily K, member 5 2.00068

decreased expression

Symbol Name Standardized Value
THAP11 THAP domain containing 11 -4.81109
HSPA8 heat shock 70kDa protein 8 -4.03502
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.93312
HAT1 histone acetyltransferase 1 -3.86868
CAB39 calcium binding protein 39 -3.86551
MAPK13 mitogen-activated protein kinase 13 -3.72824
TLCD3A TLC domain containing 3A -3.70434
HMG20B high mobility group 20B -3.16192
MSMO1 methylsterol monooxygenase 1 -3.02776
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.80315
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.79782
RPS5 ribosomal protein S5 -2.79123
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.77592
TNIP1 TNFAIP3 interacting protein 1 -2.67812
RPL34 ribosomal protein L34 -2.38397
RPL6 ribosomal protein L6 -2.28575
EIF3D eukaryotic translation initiation factor 3, subunit D -2.2697
TRIP12 thyroid hormone receptor interactor 12 -2.22423
RPL11 ribosomal protein L11 -2.20132
RPS27 ribosomal protein S27 -2.18569
RPS29 ribosomal protein S29 -2.16171
TBX3 T-box 3 -2.14813
ACTG1 actin gamma 1 -2.14091
EIF3L eukaryotic translation initiation factor 3, subunit L -2.11087
RPL21 ribosomal protein L21 -2.08793
RPS11 ribosomal protein S11 -2.05056
MIDEAS mitotic deacetylase associated SANT domain protein -2.03658
NOP53 NOP53 ribosome biogenesis factor -2.03639
OLA1 Obg-like ATPase 1 -2.036
ZNF266 zinc finger protein 266 -2.02214
JAK1 Janus kinase 1 -2.01865
RPL37 ribosomal protein L37 -2.00677