CRCGN016_MCF10A.WT.HP_24H:O16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyanazine 98.4 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

66 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 6.06472
RGS2 regulator of G-protein signaling 2 5.16312
DHRS2 dehydrogenase/reductase (SDR family) member 2 4.08003
ACAA1 acetyl-CoA acyltransferase 1 4.01282
FKBP14 FK506 binding protein 14, 22 kDa 3.90284
FOSL1 FOS-like antigen 1 3.6378
HBB hemoglobin, beta 3.62185
PTPN1 protein tyrosine phosphatase, non-receptor type 1 3.07266
SPAG4 sperm associated antigen 4 3.01923
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.94764
STX1A syntaxin 1A (brain) 2.90054
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.81335
MICALL1 MICAL-like 1 2.779
CDK7 cyclin-dependent kinase 7 2.68653
DUSP4 dual specificity phosphatase 4 2.65882
TICAM1 toll-like receptor adaptor molecule 1 2.64016
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 2.62074
CAB39 calcium binding protein 39 2.58655
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.45548
RAB21 RAB21, member RAS oncogene family 2.43979
SQOR sulfide quinone oxidoreductase 2.37074
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.32568
LRP10 low density lipoprotein receptor-related protein 10 2.23836
FHL2 four and a half LIM domains 2 2.21722
NGLY1 N-glycanase 1 2.21327
SYTL2 synaptotagmin-like 2 2.12642
MAPK9 mitogen-activated protein kinase 9 2.11977
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.11975
INPP1 inositol polyphosphate-1-phosphatase 2.1065
HOXA5 homeobox A5 2.07051
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.06722
FGD6 FYVE, RhoGEF and PH domain containing 6 2.04758
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 2.03769
PPARG peroxisome proliferator-activated receptor gamma 2.01533

decreased expression

Symbol Name Standardized Value
ARID4B AT rich interactive domain 4B (RBP1-like) -5.17648
PSRC1 proline/serine-rich coiled-coil 1 -4.8553
NCAPD2 non-SMC condensin I complex, subunit D2 -4.05468
SCYL3 SCY1-like 3 (S. cerevisiae) -3.84026
GDF15 growth differentiation factor 15 -3.78591
NLRP4 NLR family, pyrin domain containing 4 -3.40867
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -3.29293
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.97338
KIF14 kinesin family member 14 -2.90219
KEAP1 kelch-like ECH-associated protein 1 -2.88911
ATF5 activating transcription factor 5 -2.87402
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.80758
JADE2 jade family PHD finger 2 -2.67029
HTRA1 HtrA serine peptidase 1 -2.54353
COG4 component of oligomeric golgi complex 4 -2.52175
TSC22D3 TSC22 domain family, member 3 -2.50972
TSPAN4 tetraspanin 4 -2.34642
INTS3 integrator complex subunit 3 -2.30558
PHGDH phosphoglycerate dehydrogenase -2.30391
USP5 ubiquitin specific peptidase 5 (isopeptidase T) -2.26861
DCAF11 DDB1 and CUL4 associated factor 11 -2.24996
GALE UDP-galactose-4-epimerase -2.19998
SH3D19 SH3 domain containing 19 -2.19917
NOTCH1 notch 1 -2.14544
UBE2C ubiquitin-conjugating enzyme E2C -2.14056
KRT14 keratin 14, type I -2.13374
CIRBP cold inducible RNA binding protein -2.12563
INSIG1 insulin induced gene 1 -2.10457
OARD1 O-acyl-ADP-ribose deacylase 1 -2.09772
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -2.09743
TLCD3A TLC domain containing 3A -2.05269
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 -2.01159