CRCGN016_MCF10A.WT.HP_24H:O17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description cyanazine 32.8 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

67 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ACAA1 acetyl-CoA acyltransferase 1 5.13797
LAGE3 L antigen family, member 3 5.10556
SPAG4 sperm associated antigen 4 5.01872
HBA1 hemoglobin, alpha 1 4.80814
KCTD5 potassium channel tetramerization domain containing 5 4.58031
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.41837
WASF3 WAS protein family, member 3 4.29677
AGR2 anterior gradient 2 3.73261
TBX2 T-box 2 3.68994
HBB hemoglobin, beta 3.52025
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.50216
CGRRF1 cell growth regulator with ring finger domain 1 3.23705
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.86728
LSR lipolysis stimulated lipoprotein receptor 2.82066
WIF1 WNT inhibitory factor 1 2.7517
NINJ2 ninjurin 2 2.416
SOCS2 suppressor of cytokine signaling 2 2.40562
ANKRD28 ankyrin repeat domain 28 2.40061
C1GALT1C1 C1GALT1-specific chaperone 1 2.36938
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 2.22463
TBC1D31 TBC1 domain family, member 31 2.21117
TBPL1 TBP-like 1 2.19624
GMFB glia maturation factor, beta 2.16111
PTER phosphotriesterase related 2.1503
RMDN1 regulator of microtubule dynamics 1 2.11922
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.10979
HOXA5 homeobox A5 2.10758
CD53 CD53 molecule 2.10338
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 2.09172
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.07613
TFB1M transcription factor B1, mitochondrial 2.06084
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 2.05829
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 2.04193
METTL8 methyltransferase like 8 2.03321
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 2.01089
F8A2 coagulation factor VIII-associated 2 2.00761

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -7.07511
UFM1 ubiquitin-fold modifier 1 -5.16443
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -4.90593
SGK1 serum/glucocorticoid regulated kinase 1 -4.82851
S100A8 S100 calcium binding protein A8 -4.80814
TRIB3 tribbles pseudokinase 3 -4.08885
JMJD6 jumonji domain containing 6 -4.02995
CAB39 calcium binding protein 39 -3.82803
NUSAP1 nucleolar and spindle associated protein 1 -3.80036
ANXA2 annexin A2 -3.60471
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.45786
ERC2 ELKS/RAB6-interacting/CAST family member 2 -3.22674
KRT5 keratin 5, type II -3.07353
TRAP1 TNF receptor-associated protein 1 -2.84597
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.68813
TENT4A terminal nucleotidyltransferase 4A -2.67445
CPSF4 cleavage and polyadenylation specific factor 4, 30kDa -2.66714
MAD2L1BP MAD2L1 binding protein -2.35313
CRISP3 cysteine-rich secretory protein 3 -2.32341
NOTCH1 notch 1 -2.30604
ARID4B AT rich interactive domain 4B (RBP1-like) -2.28396
KLHL21 kelch-like family member 21 -2.19823
NFE2L1 nuclear factor, erythroid 2-like 1 -2.16247
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 -2.15761
NLRP4 NLR family, pyrin domain containing 4 -2.14864
HLA-DRA major histocompatibility complex, class II, DR alpha -2.11494
ZNF768 zinc finger protein 768 -2.09763
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -2.06936
FAN1 FANCD2/FANCI-associated nuclease 1 -2.01022
LTK leukocyte receptor tyrosine kinase -2.00144
KRT15 keratin 15, type I -2.00069