CRCGN016_MCF10A.WT.HP_24H:O19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tegafur 102.01 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

171 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 8.61505
DDB2 damage-specific DNA binding protein 2, 48kDa 3.8033
CCNE2 cyclin E2 3.73482
FAT1 FAT atypical cadherin 1 3.70762
FCHO1 FCH domain only 1 3.675
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.61161
SPAG4 sperm associated antigen 4 3.60178
RGS2 regulator of G-protein signaling 2 3.5552
CASP7 caspase 7, apoptosis-related cysteine peptidase 3.53577
CGRRF1 cell growth regulator with ring finger domain 1 3.50365
INPP1 inositol polyphosphate-1-phosphatase 3.4363
GATA2 GATA binding protein 2 3.35105
STAP2 signal transducing adaptor family member 2 3.344
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.31138
LOXL1 lysyl oxidase-like 1 3.26768
PCNA proliferating cell nuclear antigen 3.23766
BAX BCL2-associated X protein 3.17021
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 3.056
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.81922
GCH1 GTP cyclohydrolase 1 2.81141
COMP cartilage oligomeric matrix protein 2.7899
FDXR ferredoxin reductase 2.62983
CCP110 centriolar coiled coil protein 110kDa 2.61044
CCNE1 cyclin E1 2.60742
EGLN3 egl-9 family hypoxia-inducible factor 3 2.5256
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 2.473
PHLDA3 pleckstrin homology-like domain, family A, member 3 2.44403
SCCPDH saccharopine dehydrogenase (putative) 2.42848
RAP1GAP RAP1 GTPase activating protein 2.40194
BMP2K BMP2 inducible kinase 2.39771
SESN1 sestrin 1 2.39102
DCK deoxycytidine kinase 2.36336
SIGLEC15 sialic acid binding Ig-like lectin 15 2.34043
UNG uracil-DNA glycosylase 2.32359
NAGK N-acetylglucosamine kinase 2.27753
DUSP14 dual specificity phosphatase 14 2.25562
FASN fatty acid synthase 2.24359
FLT4 fms-related tyrosine kinase 4 2.24005
VASH2 vasohibin 2 2.23397
CTSK cathepsin K 2.19174
ZNF467 zinc finger protein 467 2.18511
ARHGAP25 Rho GTPase activating protein 25 2.18193
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide 2.17334
ANKRD37 ankyrin repeat domain 37 2.16889
MAB21L1 mab-21-like 1 (C. elegans) 2.16366
WIF1 WNT inhibitory factor 1 2.16256
BSDC1 BSD domain containing 1 2.15496
CADM1 cell adhesion molecule 1 2.15017
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.14238
RMDN3 regulator of microtubule dynamics 3 2.12724
TLR3 toll-like receptor 3 2.12581
ZNF548 zinc finger protein 548 2.11269
TMEM140 transmembrane protein 140 2.09204
TRIM22 tripartite motif containing 22 2.08773
GSTM4 glutathione S-transferase mu 4 2.07631
LIMK2 LIM domain kinase 2 2.06874
MOXD1 monooxygenase, DBH-like 1 2.05967
ASL argininosuccinate lyase 2.05651
ADAM2 ADAM metallopeptidase domain 2 2.05322
ZNF136 zinc finger protein 136 2.05277
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.04302
OLFML1 olfactomedin-like 1 2.0356
CCDC15 coiled-coil domain containing 15 2.03458
P2RY14 purinergic receptor P2Y, G-protein coupled, 14 2.03269
AGR2 anterior gradient 2 2.03113
DAAM2 dishevelled associated activator of morphogenesis 2 2.03064
RABGGTA Rab geranylgeranyltransferase, alpha subunit 2.02937
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) 2.02547
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1 2.01069
ATG4A autophagy related 4A, cysteine peptidase 2.00864
PLEKHO1 pleckstrin homology domain containing, family O member 1 2.00689
MMUT methylmalonyl-CoA mutase 2.0037
MMP11 matrix metallopeptidase 11 2.00216
MPC2 mitochondrial pyruvate carrier 2 2.00005

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -9.53312
PLK1 polo-like kinase 1 -9.28951
UBE2C ubiquitin-conjugating enzyme E2C -9.09734
PSRC1 proline/serine-rich coiled-coil 1 -7.83197
KIF20A kinesin family member 20A -7.5308
THAP11 THAP domain containing 11 -6.96134
CDC25B cell division cycle 25B -5.87817
TOP2A topoisomerase (DNA) II alpha 170kDa -5.86724
KIF14 kinesin family member 14 -5.69418
AURKA aurora kinase A -5.60007
CCNB2 cyclin B2 -5.09222
KIF4A kinesin family member 4A -4.56192
NCAPD2 non-SMC condensin I complex, subunit D2 -4.51951
BASP1 brain abundant, membrane attached signal protein 1 -4.4445
DSG2 desmoglein 2 -4.36066
LBR lamin B receptor -4.1243
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.07071
CDCA3 cell division cycle associated 3 -3.87833
ACOT9 acyl-CoA thioesterase 9 -3.65641
CCNB1 cyclin B1 -3.61418
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.60955
CAB39 calcium binding protein 39 -3.55588
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -3.45171
PIMREG PICALM interacting mitotic regulator -3.38984
CENPA centromere protein A -3.37745
TAC4 tachykinin 4 (hemokinin) -3.3637
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.34426
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -3.2496
TPX2 TPX2, microtubule-associated -3.20916
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.19928
CCNA2 cyclin A2 -3.19927
NEK2 NIMA-related kinase 2 -3.16772
TCERG1 transcription elongation regulator 1 -3.15764
BIRC5 baculoviral IAP repeat containing 5 -3.13864
GPSM2 G-protein signaling modulator 2 -3.09078
MYC v-myc avian myelocytomatosis viral oncogene homolog -3.05043
TOMM34 translocase of outer mitochondrial membrane 34 -2.95891
DEPDC1 DEP domain containing 1 -2.91428
HJURP Holliday junction recognition protein -2.90697
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa -2.85429
VDAC1 voltage-dependent anion channel 1 -2.85395
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.82854
MSN moesin -2.81203
CD44 CD44 molecule (Indian blood group) -2.79042
TIMP1 TIMP metallopeptidase inhibitor 1 -2.78178
PTTG1 pituitary tumor-transforming 1 -2.77028
CKAP5 cytoskeleton associated protein 5 -2.73998
JADE2 jade family PHD finger 2 -2.69212
FAM168B family with sequence similarity 168, member B -2.66141
TTK TTK protein kinase -2.65839
DHRS7 dehydrogenase/reductase (SDR family) member 7 -2.60074
CDCA8 cell division cycle associated 8 -2.58678
RAI1 retinoic acid induced 1 -2.53376
RACGAP1 Rac GTPase activating protein 1 -2.51732
CCNF cyclin F -2.49555
TACC3 transforming, acidic coiled-coil containing protein 3 -2.45891
CDC25C cell division cycle 25C -2.45886
CDKN3 cyclin-dependent kinase inhibitor 3 -2.4174
MKI67 marker of proliferation Ki-67 -2.39685
LOC124908558 X antigen family member 1-like -2.35276
SYNGAP1 synaptic Ras GTPase activating protein 1 -2.3459
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5 -2.33713
KLHL21 kelch-like family member 21 -2.32983
TXNDC9 thioredoxin domain containing 9 -2.32922
CEP55 centrosomal protein 55kDa -2.32821
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.32819
KIF23 kinesin family member 23 -2.32598
TRAP1 TNF receptor-associated protein 1 -2.30744
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.25858
TROAP trophinin associated protein -2.24657
GOLT1B golgi transport 1B -2.23313
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.21344
TOP2B topoisomerase (DNA) II beta 180kDa -2.20616
NGRN neugrin, neurite outgrowth associated -2.20475
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.20318
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.20315
DHX29 DEAH (Asp-Glu-Ala-His) box polypeptide 29 -2.17887
FBXO7 F-box protein 7 -2.1627
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -2.13622
CD81 CD81 molecule -2.13367
CKAP2 cytoskeleton associated protein 2 -2.12088
MT1X metallothionein 1X -2.11937
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.11044
BORA bora, aurora kinase A activator -2.1097
BICRAL BICRA like chromatin remodeling complex associated protein -2.10545
TATDN2 TatD DNase domain containing 2 -2.09708
OXSR1 oxidative stress responsive 1 -2.09438
CETN3 centrin, EF-hand protein, 3 -2.07288
CDK5RAP1 CDK5 regulatory subunit associated protein 1 -2.06443
COPZ1 coatomer protein complex, subunit zeta 1 -2.05649
CENPF centromere protein F, 350/400kDa -2.05433
CENPB centromere protein B, 80kDa -2.04798
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.04351
KIF18A kinesin family member 18A -2.03755
MRPS2 mitochondrial ribosomal protein S2 -2.02734
WDR74 WD repeat domain 74 -2.02641
PRC1 protein regulator of cytokinesis 1 -2.00333