CRCGN016_MCF10A.WT.HP_24H:O20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tegafur 34.0 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

197 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CDPF1 cysteine-rich, DPF motif domain containing 1 6.8744
HBA1 hemoglobin, alpha 1 5.7178
HBB hemoglobin, beta 4.96605
TICAM1 toll-like receptor adaptor molecule 1 4.78761
COMP cartilage oligomeric matrix protein 4.60079
SPAG4 sperm associated antigen 4 4.10723
PRKCQ protein kinase C, theta 4.07068
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 3.91716
CCP110 centriolar coiled coil protein 110kDa 3.91362
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 3.80739
CCNE2 cyclin E2 3.37295
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.33102
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.2384
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.17761
DDB2 damage-specific DNA binding protein 2, 48kDa 3.15218
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial 3.04344
IFI6 interferon, alpha-inducible protein 6 2.97053
GTPBP8 GTP-binding protein 8 (putative) 2.90701
MNDA myeloid cell nuclear differentiation antigen 2.84472
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 2.83779
RAB27A RAB27A, member RAS oncogene family 2.82275
LGALS9C lectin, galactoside-binding, soluble, 9C 2.7384
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.72491
FKBP14 FK506 binding protein 14, 22 kDa 2.72192
TRIM5 tripartite motif containing 5 2.71811
LGMN legumain 2.7122
FLCN folliculin 2.69169
FGR FGR proto-oncogene, Src family tyrosine kinase 2.68186
APOL6 apolipoprotein L, 6 2.60934
CCL2 chemokine (C-C motif) ligand 2 2.59031
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 2.57828
BAX BCL2-associated X protein 2.50413
MAB21L1 mab-21-like 1 (C. elegans) 2.46466
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 2.45924
TFEB transcription factor EB 2.44954
CLN8 ceroid-lipofuscinosis, neuronal 8 (epilepsy, progressive with mental retardation) 2.43911
BEND5 BEN domain containing 5 2.43648
TCEA2 transcription elongation factor A (SII), 2 2.4075
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) 2.40523
LDAF1 lipid droplet assembly factor 1 2.38632
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.38056
SLC47A1 solute carrier family 47 (multidrug and toxin extrusion), member 1 2.37961
CYBB cytochrome b-245, beta polypeptide 2.37774
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 2.36553
MX1 MX dynamin-like GTPase 1 2.35345
TMEM45A transmembrane protein 45A 2.35211
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.32849
TOPBP1 topoisomerase (DNA) II binding protein 1 2.32638
COPZ2 coatomer protein complex, subunit zeta 2 2.31079
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 2.29672
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.28992
RAP1GAP RAP1 GTPase activating protein 2.28796
PSMC3IP PSMC3 interacting protein 2.28114
MTCL1 microtubule crosslinking factor 1 2.27407
PPP1R17 protein phosphatase 1, regulatory subunit 17 2.27105
TBCCD1 TBCC domain containing 1 2.27082
TRIM22 tripartite motif containing 22 2.25349
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 2.2457
ZNF136 zinc finger protein 136 2.23159
TBC1D8B TBC1 domain family, member 8B (with GRAM domain) 2.22672
IRAK4 interleukin-1 receptor-associated kinase 4 2.21061
IRF9 interferon regulatory factor 9 2.20998
PPP1R13L protein phosphatase 1, regulatory subunit 13 like 2.20911
CATSPER2 cation channel, sperm associated 2 2.19844
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.19578
C5 complement component 5 2.18879
NCKIPSD NCK interacting protein with SH3 domain 2.18802
TRIM16 tripartite motif containing 16 2.18628
WDR76 WD repeat domain 76 2.17977
ADAM28 ADAM metallopeptidase domain 28 2.17717
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 2.17252
CGRRF1 cell growth regulator with ring finger domain 1 2.17081
ABHD18 abhydrolase domain containing 18 2.16973
RBBP5 retinoblastoma binding protein 5 2.15807
PGPEP1 pyroglutamyl-peptidase I 2.15203
ZNF506 zinc finger protein 506 2.14854
DGKG diacylglycerol kinase, gamma 90kDa 2.14324
RGS2 regulator of G-protein signaling 2 2.13672
TBXA2R thromboxane A2 receptor 2.13405
WNT2 wingless-type MMTV integration site family member 2 2.12447
CDC45 cell division cycle 45 2.12152
SCGB2A1 secretoglobin, family 2A, member 1 2.11666
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.11301
RHEX regulator of hemoglobinization and erythroid cell expansion 2.09904
CREB5 cAMP responsive element binding protein 5 2.0985
HCFC2 host cell factor C2 2.08004
ZIM3 zinc finger, imprinted 3 2.07825
CCDC15 coiled-coil domain containing 15 2.07275
OLR1 oxidized low density lipoprotein (lectin-like) receptor 1 2.06879
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.0645
ATP10D ATPase, class V, type 10D 2.0498
DCLRE1B DNA cross-link repair 1B 2.04536
ECM2 extracellular matrix protein 2, female organ and adipocyte specific 2.03893
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.03581
GOLGA1 golgin A1 2.03562
LY6G5C lymphocyte antigen 6 complex, locus G5C 2.03553
TCTN1 tectonic family member 1 2.03002
NAA40 N(alpha)-acetyltransferase 40, NatD catalytic subunit 2.02732
MSX2 msh homeobox 2 2.02502
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 2.02368
TAF5L TAF5-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa 2.02107
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.0203
GPC4 glypican 4 2.02009
CDC6 cell division cycle 6 2.01802
ADM adrenomedullin 2.01706
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.01522
TYROBP TYRO protein tyrosine kinase binding protein 2.00738

decreased expression

Symbol Name Standardized Value
UBE2C ubiquitin-conjugating enzyme E2C -9.24763
CDC20 cell division cycle 20 -8.72895
PLK1 polo-like kinase 1 -8.00267
KIF14 kinesin family member 14 -6.5892
PSRC1 proline/serine-rich coiled-coil 1 -6.17779
AURKA aurora kinase A -5.73777
KIF20A kinesin family member 20A -5.61799
TOP2A topoisomerase (DNA) II alpha 170kDa -5.13588
NCAPD2 non-SMC condensin I complex, subunit D2 -4.70658
ARID4B AT rich interactive domain 4B (RBP1-like) -4.57393
BASP1 brain abundant, membrane attached signal protein 1 -4.37848
PSIP1 PC4 and SFRS1 interacting protein 1 -4.22605
HMG20B high mobility group 20B -4.17229
CAB39 calcium binding protein 39 -4.09618
LBR lamin B receptor -3.89927
ENOPH1 enolase-phosphatase 1 -3.76477
CENPA centromere protein A -3.72244
THAP11 THAP domain containing 11 -3.68482
PIMREG PICALM interacting mitotic regulator -3.68476
CD320 CD320 molecule -3.64079
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.61144
TOMM34 translocase of outer mitochondrial membrane 34 -3.61006
CDC25B cell division cycle 25B -3.34266
CCNB2 cyclin B2 -3.34241
NUSAP1 nucleolar and spindle associated protein 1 -3.31282
CCNB1 cyclin B1 -3.29563
TROAP trophinin associated protein -3.28542
KIF4A kinesin family member 4A -3.24367
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -3.20944
SGK1 serum/glucocorticoid regulated kinase 1 -3.2067
TPX2 TPX2, microtubule-associated -3.11409
TES testin LIM domain protein -3.10531
CDCA3 cell division cycle associated 3 -3.02055
CENPF centromere protein F, 350/400kDa -2.98942
PTTG1 pituitary tumor-transforming 1 -2.97326
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.95193
HJURP Holliday junction recognition protein -2.95043
ADI1 acireductone dioxygenase 1 -2.91208
CDCA8 cell division cycle associated 8 -2.90401
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -2.82807
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.79976
NEK2 NIMA-related kinase 2 -2.7708
PCCB propionyl CoA carboxylase, beta polypeptide -2.75253
SLAMF1 signaling lymphocytic activation molecule family member 1 -2.70296
AURKB aurora kinase B -2.6773
MT1X metallothionein 1X -2.67556
UBE2S ubiquitin-conjugating enzyme E2S -2.62385
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.59972
BIRC5 baculoviral IAP repeat containing 5 -2.59574
CDC25C cell division cycle 25C -2.56606
DLGAP3 discs, large (Drosophila) homolog-associated protein 3 -2.55793
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.55571
RBM6 RNA binding motif protein 6 -2.54088
CKAP5 cytoskeleton associated protein 5 -2.53063
NDC80 NDC80 kinetochore complex component -2.45947
CCNF cyclin F -2.44945
PSMG2 proteasome (prosome, macropain) assembly chaperone 2 -2.44809
CCNA2 cyclin A2 -2.44579
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.44566
RALGDS ral guanine nucleotide dissociation stimulator -2.42472
KIF23 kinesin family member 23 -2.40481
TACC3 transforming, acidic coiled-coil containing protein 3 -2.37617
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.33688
RPN2 ribophorin II -2.33133
KIF18A kinesin family member 18A -2.2959
HMGB2 high mobility group box 2 -2.2883
FBXO7 F-box protein 7 -2.28766
TUBB6 tubulin, beta 6 class V -2.25856
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) -2.21273
OXSR1 oxidative stress responsive 1 -2.21234
PUM3 pumilio RNA binding family member 3 -2.19979
CDKN3 cyclin-dependent kinase inhibitor 3 -2.17353
MAP3K4 mitogen-activated protein kinase kinase kinase 4 -2.16571
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.16254
NUP93 nucleoporin 93kDa -2.16243
SPAG5 sperm associated antigen 5 -2.16136
TTK TTK protein kinase -2.15193
CEP55 centrosomal protein 55kDa -2.14429
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 -2.09445
LRRC8D leucine rich repeat containing 8 family, member D -2.09173
CORO1A coronin, actin binding protein, 1A -2.09164
COL9A3 collagen, type IX, alpha 3 -2.07941
ANXA2 annexin A2 -2.0704
MED17 mediator complex subunit 17 -2.05786
REXO4 REX4, RNA exonuclease 4 homolog (S. cerevisiae) -2.0544
TAC4 tachykinin 4 (hemokinin) -2.04784
WDR12 WD repeat domain 12 -2.04112
NGRN neugrin, neurite outgrowth associated -2.04023
IGFBP1 insulin-like growth factor binding protein 1 -2.01616
CLTC clathrin, heavy chain (Hc) -2.00673