CRCGN016_MCF10A.WT.HP_24H:O22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tolazamide 100.97 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 3.8703
HBB hemoglobin, beta 3.79848
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.49051
WIF1 WNT inhibitory factor 1 2.41217
HBA1 hemoglobin, alpha 1 2.21829
COMMD8 COMM domain containing 8 2.19758
CADM1 cell adhesion molecule 1 2.16705
DMAC2L distal membrane arm assembly component 2 like 2.14259
ZNF26 zinc finger protein 26 2.08435
CALM2 calmodulin 2 (phosphorylase kinase, delta) 2.07537
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.06584
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 2.05884
SSBP2 single-stranded DNA binding protein 2 2.04713
ABHD18 abhydrolase domain containing 18 2.04677

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -6.40203
ZDHHC6 zinc finger, DHHC-type containing 6 -4.31774
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -4.01269
HMG20B high mobility group 20B -3.3516
NUP85 nucleoporin 85kDa -2.9721
JMJD6 jumonji domain containing 6 -2.96041
CBR3 carbonyl reductase 3 -2.84593
CANT1 calcium activated nucleotidase 1 -2.64165
KRT14 keratin 14, type I -2.58987
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.57981
WBP2 WW domain binding protein 2 -2.55636
KCTD2 potassium channel tetramerization domain containing 2 -2.50325
SAP30BP SAP30 binding protein -2.42694
RHBDF2 rhomboid 5 homolog 2 (Drosophila) -2.32934
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.18176
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.04601
RBM10 RNA binding motif protein 10 -2.02118