CRCGN016_MCF10A.WT.HP_24H:O23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tolazamide 33.66 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:O23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 4.48871
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.64566
GATA2 GATA binding protein 2 3.23592
CCL2 chemokine (C-C motif) ligand 2 2.87638
GHR growth hormone receptor 2.77556
FRS2 fibroblast growth factor receptor substrate 2 2.77474
ABHD11 abhydrolase domain containing 11 2.7382
CTSD cathepsin D 2.68626
ITFG1 integrin alpha FG-GAP repeat containing 1 2.66011
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 2.59262
PLGLB2 plasminogen-like B2 2.47696
ARL4C ADP-ribosylation factor-like 4C 2.40238
ZNF8 zinc finger protein 8 2.37444
CAPN1 calpain 1, (mu/I) large subunit 2.31266
FSD1 fibronectin type III and SPRY domain containing 1 2.2861
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1 2.28008
RDH16 retinol dehydrogenase 16 (all-trans) 2.26578
HIRIP3 HIRA interacting protein 3 2.21853
BAX BCL2-associated X protein 2.18909
STK10 serine/threonine kinase 10 2.18534
CYB5RL cytochrome b5 reductase-like 2.18128
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 2.16229
PRRG2 proline rich Gla (G-carboxyglutamic acid) 2 2.10952
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.10792
ZNF606 zinc finger protein 606 2.07664
HGFAC HGF activator 2.05419
CYP2A7 cytochrome P450, family 2, subfamily A, polypeptide 7 2.0393

decreased expression

Symbol Name Standardized Value
TLCD3A TLC domain containing 3A -5.62542
ZDHHC6 zinc finger, DHHC-type containing 6 -4.13541
HAT1 histone acetyltransferase 1 -4.07261
PPIC peptidylprolyl isomerase C (cyclophilin C) -3.7631
GOLT1B golgi transport 1B -3.73208
TRAPPC3 trafficking protein particle complex 3 -3.69345
BASP1 brain abundant, membrane attached signal protein 1 -3.21273
THAP11 THAP domain containing 11 -2.66993
CORO1A coronin, actin binding protein, 1A -2.55105
RRAGA Ras-related GTP binding A -2.46668
FAIM Fas apoptotic inhibitory molecule -2.40683
ARID4B AT rich interactive domain 4B (RBP1-like) -2.36055
XPO7 exportin 7 -2.26986
OXA1L oxidase (cytochrome c) assembly 1-like -2.21621
NLRP2B NLR family pyrin domain containing 2B -2.19113
RETREG3 reticulophagy regulator family member 3 -2.15951
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.09308
KDM3A lysine (K)-specific demethylase 3A -2.09257
BMAL2 basic helix-loop-helix ARNT like 2 -2.03996
KRT14 keratin 14, type I -2.03328
RECQL RecQ helicase-like -2.01345