CRCGN016_MCF10A.WT.HP_24H:P02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlormadinone acetate 33.04 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

131 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:P02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ABHD6 abhydrolase domain containing 6 4.50531
FHL2 four and a half LIM domains 2 3.84429
E2F2 E2F transcription factor 2 3.79378
NUCB2 nucleobindin 2 3.39272
CXCR4 chemokine (C-X-C motif) receptor 4 3.14203
DUSP4 dual specificity phosphatase 4 2.75179
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 2.72058
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.64136
GLRX glutaredoxin (thioltransferase) 2.54047
CCL2 chemokine (C-C motif) ligand 2 2.5046
LRP10 low density lipoprotein receptor-related protein 10 2.45667
CBARP CACN subunit beta associated regulatory protein 2.43945
IER3 immediate early response 3 2.42946
ASB9 ankyrin repeat and SOCS box containing 9 2.40228
SUSD5 sushi domain containing 5 2.36441
H1-1 H1.1 linker histone, cluster member 2.33322
ANGPTL8 angiopoietin like 8 2.33192
S100A4 S100 calcium binding protein A4 2.33144
TMEM41B transmembrane protein 41B 2.33038
RPN1 ribophorin I 2.32926
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.32566
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 2.32272
SYNC syncoilin, intermediate filament protein 2.31602
EMC10 ER membrane protein complex subunit 10 2.29857
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.29379
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.27708
TAF13 TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2.26256
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase 2.26065
ZBTB35 zinc finger and BTB domain containing 35 2.25783
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.25591
CALU calumenin 2.2402
PHF14 PHD finger protein 14 2.2207
RAG2 recombination activating gene 2 2.21458
FBXO11 F-box protein 11 2.21321
FAM50A family with sequence similarity 50, member A 2.20585
FKBP14 FK506 binding protein 14, 22 kDa 2.20498
DPY19L1 dpy-19-like 1 (C. elegans) 2.18517
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.15826
GPR68 G protein-coupled receptor 68 2.1582
MMRN1 multimerin 1 2.15491
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.15355
QRICH1 glutamine-rich 1 2.14955
CCR8 chemokine (C-C motif) receptor 8 2.13388
ZNRF2 zinc and ring finger 2, E3 ubiquitin protein ligase 2.12248
EPN2 epsin 2 2.09743
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.09687
EOGT EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase 2.09473
ACTA1 actin, alpha 1, skeletal muscle 2.08714
SEC24D SEC24 family member D 2.08358
KLHDC2 kelch domain containing 2 2.07887
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.07719
ZNF254 zinc finger protein 254 2.073
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 2.06932
DENND5B DENN/MADD domain containing 5B 2.06124
SQSTM1 sequestosome 1 2.05498
NCK2 NCK adaptor protein 2 2.05173
BRDT bromodomain, testis-specific 2.04864
ITGB5 integrin, beta 5 2.03339
HOXD10 homeobox D10 2.0311
FBXO24 F-box protein 24 2.01457
HOXA11 homeobox A11 2.01259
PROCR protein C receptor, endothelial 2.00255

decreased expression

Symbol Name Standardized Value
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -6.62406
RGS2 regulator of G-protein signaling 2 -5.12266
CDK4 cyclin-dependent kinase 4 -3.83581
BID BH3 interacting domain death agonist -3.81801
DCK deoxycytidine kinase -3.74118
COG2 component of oligomeric golgi complex 2 -3.435
GADD45B growth arrest and DNA-damage-inducible, beta -3.38049
ADRB2 adrenoceptor beta 2, surface -3.14151
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.90281
ACTR10 actin-related protein 10 homolog (S. cerevisiae) -2.87681
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.87514
FZD7 frizzled class receptor 7 -2.84993
CNIH1 cornichon family AMPA receptor auxiliary protein 1 -2.79876
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast) -2.72866
TSC22D3 TSC22 domain family, member 3 -2.72856
SCD5 stearoyl-CoA desaturase 5 -2.64498
TREM1 triggering receptor expressed on myeloid cells 1 -2.63926
RXYLT1 ribitol xylosyltransferase 1 -2.5878
NLRP2B NLR family pyrin domain containing 2B -2.53621
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.49688
ARL2 ADP-ribosylation factor-like 2 -2.47354
NFIL3 nuclear factor, interleukin 3 regulated -2.44208
ATP5PO ATP synthase peripheral stalk subunit OSCP -2.41748
HSD17B10 hydroxysteroid (17-beta) dehydrogenase 10 -2.41727
LYRM4 LYR motif containing 4 -2.39945
AP5M1 adaptor-related protein complex 5, mu 1 subunit -2.38725
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.37918
POLA2 polymerase (DNA directed), alpha 2, accessory subunit -2.34207
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.29519
MEFV Mediterranean fever -2.29297
DAPL1 death associated protein-like 1 -2.27658
RPS5 ribosomal protein S5 -2.27129
LYSET lysosomal enzyme trafficking factor -2.26036
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.24419
EAPP E2F-associated phosphoprotein -2.23269
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.19006
SMYD5 SMYD family member 5 -2.18452
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.17062
VIPAS39 VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog -2.17051
APIP APAF1 interacting protein -2.15781
SRBD1 S1 RNA binding domain 1 -2.14425
ARID4A AT rich interactive domain 4A (RBP1-like) -2.14355
BZW2 basic leucine zipper and W2 domains 2 -2.14205
ZNHIT6 zinc finger, HIT-type containing 6 -2.13686
ANAPC15 anaphase promoting complex subunit 15 -2.1357
PALB2 partner and localizer of BRCA2 -2.13347
ZNF528 zinc finger protein 528 -2.1325
NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa -2.13204
EIF1B eukaryotic translation initiation factor 1B -2.12996
APH1A APH1A gamma secretase subunit -2.12994
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.11281
ZNF274 zinc finger protein 274 -2.11133
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.11109
PNO1 partner of NOB1 homolog (S. cerevisiae) -2.10884
THAP12 THAP domain containing 12 -2.08828
AP3M2 adaptor-related protein complex 3, mu 2 subunit -2.08066
METTL1 methyltransferase like 1 -2.07817
RPP40 ribonuclease P/MRP 40kDa subunit -2.06741
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like -2.06494
RPL36 ribosomal protein L36 -2.05288
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.03786
TRAPPC2L trafficking protein particle complex 2-like -2.03221
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.03147
ZNF134 zinc finger protein 134 -2.02889
NUTF2 nuclear transport factor 2 -2.01927
OXCT1 3-oxoacid CoA transferase 1 -2.01617
SDHAF3 succinate dehydrogenase complex assembly factor 3 -2.01184
MYNN myoneurin -2.00578
MRPS33 mitochondrial ribosomal protein S33 -2.00034