CRCGN016_MCF10A.WT.HP_24H:P03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlormadinone acetate 11.01 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

70 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:P03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ARID5B AT rich interactive domain 5B (MRF1-like) 5.95834
FHL2 four and a half LIM domains 2 4.06575
AGR2 anterior gradient 2 3.89446
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 3.60744
NUCB2 nucleobindin 2 3.59869
ZNF586 zinc finger protein 586 3.24203
PPARG peroxisome proliferator-activated receptor gamma 3.23693
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.91187
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 2.87949
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.83244
E2F2 E2F transcription factor 2 2.79677
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.71838
FKBP14 FK506 binding protein 14, 22 kDa 2.66553
HOXA5 homeobox A5 2.44777
KDM5D lysine (K)-specific demethylase 5D 2.44612
LOC128031832 uncharacterized LOC128031832 2.42977
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.39977
SYNGAP1 synaptic Ras GTPase activating protein 1 2.38035
CGRRF1 cell growth regulator with ring finger domain 1 2.32733
CCDC7 coiled-coil domain containing 7 2.30237
SIGLEC5 sialic acid binding Ig-like lectin 5 2.28997
CALU calumenin 2.22867
ABHD14A abhydrolase domain containing 14A 2.20704
IER3 immediate early response 3 2.19856
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 2.17094
DUSP4 dual specificity phosphatase 4 2.15262
TERF2IP telomeric repeat binding factor 2, interacting protein 2.13864
MAP3K19 mitogen-activated protein kinase kinase kinase 19 2.13391
RBP3 retinol binding protein 3, interstitial 2.12607
PLS1 plastin 1 2.12306
SUOX sulfite oxidase 2.1162
ZFC3H1 zinc finger, C3H1-type containing 2.09598
MKNK1 MAP kinase interacting serine/threonine kinase 1 2.08233
DAPK2 death-associated protein kinase 2 2.07934
ZMPSTE24 zinc metallopeptidase STE24 2.07261
FGF17 fibroblast growth factor 17 2.05853
BAX BCL2-associated X protein 2.05492
MYBPC3 myosin binding protein C, cardiac 2.04143
GRB2 growth factor receptor-bound protein 2 2.0286
SMAD3 SMAD family member 3 2.02673
GALP galanin-like peptide 2.02238
CRLF1 cytokine receptor-like factor 1 2.01138
FKBP6 FK506 binding protein 6, 36kDa 2.00729

decreased expression

Symbol Name Standardized Value
TRAP1 TNF receptor-associated protein 1 -4.11975
RGS2 regulator of G-protein signaling 2 -4.07932
PSRC1 proline/serine-rich coiled-coil 1 -3.51544
CDC25B cell division cycle 25B -3.51046
S100A8 S100 calcium binding protein A8 -3.35759
VDAC1 voltage-dependent anion channel 1 -3.21818
ADRB2 adrenoceptor beta 2, surface -3.04348
TSC22D3 TSC22 domain family, member 3 -3.03351
SGK1 serum/glucocorticoid regulated kinase 1 -2.82703
GADD45B growth arrest and DNA-damage-inducible, beta -2.81778
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.74071
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.68805
LYPLA1 lysophospholipase I -2.67848
DERA deoxyribose-phosphate aldolase (putative) -2.46977
AXIN1 axin 1 -2.43747
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.38592
SMC1A structural maintenance of chromosomes 1A -2.36334
CDK4 cyclin-dependent kinase 4 -2.31777
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) -2.24149
FXYD6-FXYD2 FXYD6-FXYD2 readthrough -2.13041
OXCT1 3-oxoacid CoA transferase 1 -2.12734
TMEM147 transmembrane protein 147 -2.09833
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta -2.0938
NFIL3 nuclear factor, interleukin 3 regulated -2.08875
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.04536
PLPP6 phospholipid phosphatase 6 -2.02241
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.01165