CRCGN016_MCF10A.WT.HP_24H:P12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description leucomalachite green 10.98 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:P12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 4.07097
PPARG peroxisome proliferator-activated receptor gamma 4.0496
KCTD5 potassium channel tetramerization domain containing 5 3.96156
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.3555
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 3.02398
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.84384
PHGDH phosphoglycerate dehydrogenase 2.78184
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta 2.53314
OLFML2B olfactomedin-like 2B 2.3911
ZBTB35 zinc finger and BTB domain containing 35 2.36098
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.31815
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.28684
ACAA1 acetyl-CoA acyltransferase 1 2.27057
KDM5A lysine (K)-specific demethylase 5A 2.26981
WAPL WAPL cohesin release factor 2.03014
PROS1 protein S (alpha) 2.01476

decreased expression

Symbol Name Standardized Value
COG7 component of oligomeric golgi complex 7 -4.88797
CCNB1 cyclin B1 -4.00547
HSPA8 heat shock 70kDa protein 8 -3.93585
BASP1 brain abundant, membrane attached signal protein 1 -3.68764
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -3.34032
ALDOC aldolase C, fructose-bisphosphate -3.33648
TCEA2 transcription elongation factor A (SII), 2 -3.30089
SGK1 serum/glucocorticoid regulated kinase 1 -3.15857
KIF14 kinesin family member 14 -2.92387
ARID4B AT rich interactive domain 4B (RBP1-like) -2.91238
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 -2.7584
NUP85 nucleoporin 85kDa -2.71572
KRT81 keratin 81, type II -2.55664
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.51142
NFIL3 nuclear factor, interleukin 3 regulated -2.44687
ACOT9 acyl-CoA thioesterase 9 -2.41408
MRPS7 mitochondrial ribosomal protein S7 -2.37577
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.35508
CDH15 cadherin 15, type 1, M-cadherin (myotubule) -2.32128
CDK3 cyclin-dependent kinase 3 -2.27376
GADD45B growth arrest and DNA-damage-inducible, beta -2.18408
PVALB parvalbumin -2.12784
HMG20B high mobility group 20B -2.12778
TCTA T-cell leukemia translocation altered -2.11099
ESYT1 extended synaptotagmin-like protein 1 -2.05348
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -2.03067
SLC38A12 solute carrier family 38 member 12 -2.03038
KRT14 keratin 14, type I -2.01978
CARD9 caspase recruitment domain family, member 9 -2.01698