CRCGN016_MCF10A.WT.HP_24H:P16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-nitrososarcosine 97.93 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:P16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IDE insulin-degrading enzyme 4.87883
AGR2 anterior gradient 2 4.21093
EPHB2 EPH receptor B2 3.88973
PRKCH protein kinase C, eta 3.40404
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.10308
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.09041
KIF5C kinesin family member 5C 3.01088
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.98352
PXMP2 peroxisomal membrane protein 2, 22kDa 2.90886
PDLIM1 PDZ and LIM domain 1 2.79014
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.62459
ACAA1 acetyl-CoA acyltransferase 1 2.45493
CENPX centromere protein X 2.24656
GSTM2 glutathione S-transferase mu 2 (muscle) 2.24317
GIN1 gypsy retrotransposon integrase 1 2.20734
OLFML2B olfactomedin-like 2B 2.13019
RPP38 ribonuclease P/MRP 38kDa subunit 2.05231
CCDC92 coiled-coil domain containing 92 2.02079
ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2 2.02041

decreased expression

Symbol Name Standardized Value
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -8.74841
GDF15 growth differentiation factor 15 -4.96469
MRPS2 mitochondrial ribosomal protein S2 -4.61135
PCCB propionyl CoA carboxylase, beta polypeptide -4.51087
KRT14 keratin 14, type I -4.35286
HLA-G major histocompatibility complex, class I, G -3.27166
HLA-B major histocompatibility complex, class I, B -3.12483
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -3.09028
PAEP progestagen-associated endometrial protein -2.99277
COG7 component of oligomeric golgi complex 7 -2.89815
SQSTM1 sequestosome 1 -2.81115
SGK1 serum/glucocorticoid regulated kinase 1 -2.74265
HLA-A major histocompatibility complex, class I, A -2.74263
SEC16A SEC16 homolog A (S. cerevisiae) -2.65092
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.60001
HLA-C major histocompatibility complex, class I, C -2.57617
HLA-F major histocompatibility complex, class I, F -2.56547
FPGS folylpolyglutamate synthase -2.31284
TOMM34 translocase of outer mitochondrial membrane 34 -2.22084
LYPLA1 lysophospholipase I -2.21697
SLCO4C1 solute carrier organic anion transporter family, member 4C1 -2.20409
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.1629
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.02273
TUFM Tu translation elongation factor, mitochondrial -2.00349
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 -2.00266