CRCGN016_MCF10A.WT.HP_24H:P20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[2-(methylamino)-2-oxoethyl] dithiophosphate 33.68 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

24 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:P20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.14429
ACAA1 acetyl-CoA acyltransferase 1 3.6846
STAP2 signal transducing adaptor family member 2 3.04444
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.98459
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.86651
ZW10 zw10 kinetochore protein 2.6391
HSPA1A heat shock 70kDa protein 1A 2.51333
KDM5A lysine (K)-specific demethylase 5A 2.19863
NCK1 NCK adaptor protein 1 2.12139
CCNH cyclin H 2.10812
CDCA4 cell division cycle associated 4 2.0528
DNAAF2 dynein, axonemal, assembly factor 2 2.02087
AGR2 anterior gradient 2 2.00821

decreased expression

Symbol Name Standardized Value
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.26724
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.8455
RALGDS ral guanine nucleotide dissociation stimulator -3.40141
BASP1 brain abundant, membrane attached signal protein 1 -3.02709
RPA3 replication protein A3, 14kDa -3.0149
VAT1 vesicle amine transport 1 -2.74554
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.63295
HLA-G major histocompatibility complex, class I, G -2.21097
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) -2.15599
GDF15 growth differentiation factor 15 -2.15511
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 -2.06098