CRCGN016_MCF10A.WT.HP_24H:P21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-dimethyl s-[2-(methylamino)-2-oxoethyl] dithiophosphate 11.23 um perturbation at 24 h in MCF10A.WT.HP (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN016_MCF10A.WT.HP_24H:P21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.23975
VAV3 vav 3 guanine nucleotide exchange factor 4.14937
UBQLN2 ubiquilin 2 3.35551
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.31476
CGRRF1 cell growth regulator with ring finger domain 1 2.98544
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.74438
HLA-DMA major histocompatibility complex, class II, DM alpha 2.58553
MSRA methionine sulfoxide reductase A 2.5404
RBKS ribokinase 2.42777
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain 2.26311
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 2.24775
DNASE1 deoxyribonuclease I 2.12552
ZNF559-ZNF177 ZNF559-ZNF177 readthrough 2.087
ACAA1 acetyl-CoA acyltransferase 1 2.08536
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.06761
LYN LYN proto-oncogene, Src family tyrosine kinase 2.05353
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 2.03963
RNF139 ring finger protein 139 2.02993
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.02796
LRRC40 leucine rich repeat containing 40 2.01325

decreased expression

Symbol Name Standardized Value
RNF167 ring finger protein 167 -4.242
HAT1 histone acetyltransferase 1 -4.15142
KRT14 keratin 14, type I -4.08951
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -3.95746
DERA deoxyribose-phosphate aldolase (putative) -3.8513
BASP1 brain abundant, membrane attached signal protein 1 -3.68402
TRAP1 TNF receptor-associated protein 1 -3.40839
CHMP4B charged multivesicular body protein 4B -3.33563
SCYL3 SCY1-like 3 (S. cerevisiae) -3.24319
GDF15 growth differentiation factor 15 -3.09493
HMG20B high mobility group 20B -2.79504
CANT1 calcium activated nucleotidase 1 -2.78517
TOMM34 translocase of outer mitochondrial membrane 34 -2.76259
OXA1L oxidase (cytochrome c) assembly 1-like -2.75983
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.66361
TIMP1 TIMP metallopeptidase inhibitor 1 -2.38297
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5 -2.3023
FOS FBJ murine osteosarcoma viral oncogene homolog -2.19069
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -2.16818
MELK maternal embryonic leucine zipper kinase -2.11427
KIFAP3 kinesin-associated protein 3 -2.04057
TAC4 tachykinin 4 (hemokinin) -2.02471
STAP2 signal transducing adaptor family member 2 -2.02291