CRCGN017_MCF10A.TP53.M_24H:A03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

160 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:A03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.60495
AGR2 anterior gradient 2 4.5616
CXCR4 chemokine (C-X-C motif) receptor 4 4.3544
ECD ecdysoneless homolog (Drosophila) 3.7721
VGLL4 vestigial-like family member 4 2.99532
EPHB2 EPH receptor B2 2.86556
NCK1 NCK adaptor protein 1 2.84242
CNRIP1 cannabinoid receptor interacting protein 1 2.70875
TBPL1 TBP-like 1 2.69585
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.67305
HKDC1 hexokinase domain containing 1 2.5742
SP3 Sp3 transcription factor 2.533
OLFML2B olfactomedin-like 2B 2.5303
CENPE centromere protein E, 312kDa 2.4872
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 2.4585
TECR trans-2,3-enoyl-CoA reductase 2.44685
COMP cartilage oligomeric matrix protein 2.39445
ADIPOQ adiponectin, C1Q and collagen domain containing 2.3885
TPD52L2 tumor protein D52-like 2 2.38605
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 2.38503
PRB4 proline-rich protein BstNI subfamily 4 2.3229
PRH1 proline-rich protein HaeIII subfamily 1 2.3118
CISD1 CDGSH iron sulfur domain 1 2.27185
MSL2 male-specific lethal 2 homolog (Drosophila) 2.2504
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 2.23035
NECTIN4 nectin cell adhesion molecule 4 2.21675
MUC7 mucin 7, secreted 2.2127
FKBP3 FK506 binding protein 3, 25kDa 2.20215
RBP4 retinol binding protein 4, plasma 2.18265
PSMA4 proteasome (prosome, macropain) subunit, alpha type, 4 2.15225
KIN Kin17 DNA and RNA binding protein 2.1434
SKIC8 SKI8 subunit of superkiller complex 2.13952
MED28 mediator complex subunit 28 2.1274
SMIM10L1 small integral membrane protein 10 like 1 2.1185
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 2.08955
PPIH peptidylprolyl isomerase H (cyclophilin H) 2.0805
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.07855
SLIRP SRA stem-loop interacting RNA binding protein 2.07775
PHF10 PHD finger protein 10 2.07345
VIL1 villin 1 2.0688
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.06365
PRPF18 pre-mRNA processing factor 18 2.05895
HEBP2 heme binding protein 2 2.0548
NCOA6 nuclear receptor coactivator 6 2.04725
DAZAP1 DAZ associated protein 1 2.03955
OLA1 Obg-like ATPase 1 2.0298
DVL3 dishevelled segment polarity protein 3 2.02195
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide 2.0096
PAX9 paired box 9 2.0038

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -10.0
RNF167 ring finger protein 167 -5.50155
PMM2 phosphomannomutase 2 -4.99385
TES testin LIM domain protein -4.8309
HSPA8 heat shock 70kDa protein 8 -4.70635
UFM1 ubiquitin-fold modifier 1 -4.6817
UBE3C ubiquitin protein ligase E3C -4.4347
FOS FBJ murine osteosarcoma viral oncogene homolog -4.10725
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -4.0148
COG7 component of oligomeric golgi complex 7 -3.7055
RALGDS ral guanine nucleotide dissociation stimulator -3.43405
TCTA T-cell leukemia translocation altered -2.9347
SDC1 syndecan 1 -2.70918
IGFBP7 insulin-like growth factor binding protein 7 -2.6721
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -2.6631
PGBD5 piggyBac transposable element derived 5 -2.61405
KRT86 keratin 86, type II -2.54985
DENND1B DENN/MADD domain containing 1B -2.48255
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.4228
GDPD2 glycerophosphodiester phosphodiesterase domain containing 2 -2.4162
FOXL2 forkhead box L2 -2.4131
SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) -2.4089
KRT14 keratin 14, type I -2.3978
PTPRK protein tyrosine phosphatase, receptor type, K -2.38825
RNF2 ring finger protein 2 -2.3707
IGFALS insulin-like growth factor binding protein, acid labile subunit -2.34345
KDM3A lysine (K)-specific demethylase 3A -2.3397
PPP1R17 protein phosphatase 1, regulatory subunit 17 -2.33505
CPM carboxypeptidase M -2.32955
CLDN6 claudin 6 -2.32025
TCEAL2 transcription elongation factor A (SII)-like 2 -2.31865
LITAF lipopolysaccharide-induced TNF factor -2.3182
PARP8 poly (ADP-ribose) polymerase family, member 8 -2.31645
CTSW cathepsin W -2.29425
UPB1 ureidopropionase, beta -2.2897
CRTAM cytotoxic and regulatory T cell molecule -2.28695
PRUNE2 prune homolog 2 (Drosophila) -2.28013
BMP4 bone morphogenetic protein 4 -2.27635
GSDME gasdermin E -2.27635
CLXN calaxin -2.2748
MMP23B matrix metallopeptidase 23B -2.2699
RORC RAR-related orphan receptor C -2.2657
HAO2 hydroxyacid oxidase 2 (long chain) -2.25235
NDNF neuron-derived neurotrophic factor -2.244
CAPN9 calpain 9 -2.23962
MTRF1 mitochondrial translational release factor 1 -2.23675
CUBN cubilin (intrinsic factor-cobalamin receptor) -2.2364
IGFLR1 IGF-like family receptor 1 -2.23175
GYPC glycophorin C (Gerbich blood group) -2.2308
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 -2.22785
HIRIP3 HIRA interacting protein 3 -2.21775
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 -2.21605
DPYS dihydropyrimidinase -2.21005
OSBPL3 oxysterol binding protein-like 3 -2.20513
CST7 cystatin F (leukocystatin) -2.2044
SV2A synaptic vesicle glycoprotein 2A -2.20065
CFAP45 cilia and flagella associated protein 45 -2.1964
DENND2B DENN domain containing 2B -2.1896
ACY1 aminoacylase 1 -2.1894
PTHLH parathyroid hormone-like hormone -2.18423
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 -2.18275
TBX2 T-box 2 -2.18158
NLGN3 neuroligin 3 -2.1806
TCF21 transcription factor 21 -2.17545
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -2.1615
MAT1A methionine adenosyltransferase I, alpha -2.15955
NEK11 NIMA-related kinase 11 -2.1507
SLC38A4 solute carrier family 38, member 4 -2.1282
FASLG Fas ligand (TNF superfamily, member 6) -2.12727
SLC49A3 solute carrier family 49 member 3 -2.11675
GPR12 G protein-coupled receptor 12 -2.10775
HAGH hydroxyacylglutathione hydrolase -2.1016
CTSO cathepsin O -2.09935
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 -2.0991
MTTP microsomal triglyceride transfer protein -2.09195
GFOD1 glucose-fructose oxidoreductase domain containing 1 -2.0904
SPTBN4 spectrin, beta, non-erythrocytic 4 -2.0891
WFDC1 WAP four-disulfide core domain 1 -2.08895
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.08845
KLRC3 killer cell lectin-like receptor subfamily C, member 3 -2.0844
LCAT lecithin-cholesterol acyltransferase -2.0844
CENPQ centromere protein Q -2.08005
CCDC198 coiled-coil domain containing 198 -2.0765
DHX58 DEXH (Asp-Glu-X-His) box polypeptide 58 -2.0764
DPF1 D4, zinc and double PHD fingers family 1 -2.0702
NHERF4 NHERF family PDZ scaffold protein 4 -2.06845
CSDC2 cold shock domain containing C2, RNA binding -2.0646
FCN3 ficolin (collagen/fibrinogen domain containing) 3 -2.06105
EFCC1 EF-hand and coiled-coil domain containing 1 -2.05895
KDM8 lysine (K)-specific demethylase 8 -2.0588
ANKRD37 ankyrin repeat domain 37 -2.05825
JMJD4 jumonji domain containing 4 -2.0559
CFHR3 complement factor H-related 3 -2.0546
AMIGO2 adhesion molecule with Ig-like domain 2 -2.0517
HPR haptoglobin-related protein -2.048
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 -2.0377
USP2 ubiquitin specific peptidase 2 -2.03635
EXOC2 exocyst complex component 2 -2.03535
CD3E CD3e molecule, epsilon (CD3-TCR complex) -2.0346
DPF3 D4, zinc and double PHD fingers, family 3 -2.0323
RIT2 Ras-like without CAAX 2 -2.0284
SPIN2A spindlin family, member 2A -2.02785
SRPRA SRP receptor subunit alpha -2.02785
ADAT1 adenosine deaminase, tRNA-specific 1 -2.02605
PIPOX pipecolic acid oxidase -2.0199
GPR153 G protein-coupled receptor 153 -2.01587
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 -2.0143
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 -2.01425
RASL11B RAS-like, family 11, member B -2.0113
ANXA10 annexin A10 -2.0103
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 -2.0028