CRCGN017_MCF10A.TP53.M_24H:A07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetohexamide 100.71 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

253 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:A07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCP110 centriolar coiled coil protein 110kDa 5.84945
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 5.4778
E2F2 E2F transcription factor 2 5.35705
EAPP E2F-associated phosphoprotein 5.2715
TSEN2 TSEN2 tRNA splicing endonuclease subunit 5.17805
GPC1 glypican 1 4.89867
ARID5B AT rich interactive domain 5B (MRF1-like) 4.8645
AGR2 anterior gradient 2 4.7258
SNAP25 synaptosomal-associated protein, 25kDa 4.6334
ZMIZ1 zinc finger, MIZ-type containing 1 4.18505
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.16638
ADGRE5 adhesion G protein-coupled receptor E5 4.15525
DPH2 DPH2 homolog (S. cerevisiae) 4.0769
COMP cartilage oligomeric matrix protein 3.51275
SRP54 signal recognition particle 54kDa 3.4081
CDK7 cyclin-dependent kinase 7 3.34065
CRMP1 collapsin response mediator protein 1 3.32705
NSG2 neuronal vesicle trafficking associated 2 3.318
ACTL6B actin-like 6B 3.2128
OLFM1 olfactomedin 1 3.02155
MBIP MAP3K12 binding inhibitory protein 1 3.00825
TBX2 T-box 2 3.00098
GALR3 galanin receptor 3 2.99635
RUNDC3A RUN domain containing 3A 2.97127
NR4A1 nuclear receptor subfamily 4, group A, member 1 2.92545
LCN1 lipocalin 1 2.91115
NECTIN4 nectin cell adhesion molecule 4 2.84655
MEPE matrix extracellular phosphoglycoprotein 2.84155
AIRIM AFG2 interacting ribosome maturation factor 2.82175
LYN LYN proto-oncogene, Src family tyrosine kinase 2.8129
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.80298
STMN2 stathmin 2 2.79768
SLC5A2 solute carrier family 5 (sodium/glucose cotransporter), member 2 2.7722
GNG3 guanine nucleotide binding protein (G protein), gamma 3 2.76475
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.76135
WDR4 WD repeat domain 4 2.7608
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.734
ARSF arylsulfatase F 2.7186
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.66835
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.6394
ACSM2A acyl-CoA synthetase medium-chain family member 2A 2.6242
RPH3A rabphilin 3A 2.60565
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 2.5945
SPTSSA serine palmitoyltransferase, small subunit A 2.59102
ATP13A3 ATPase type 13A3 2.55307
TAGLN3 transgelin 3 2.5338
CD4 CD4 molecule 2.52865
GTF2B general transcription factor IIB 2.52305
RGS7 regulator of G-protein signaling 7 2.5145
ALOX12 arachidonate 12-lipoxygenase 2.50665
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 2.5015
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.49485
ARID4A AT rich interactive domain 4A (RBP1-like) 2.47795
ACAN aggrecan 2.4732
AOPEP aminopeptidase O (putative) 2.469
SGSH N-sulfoglucosamine sulfohydrolase 2.46848
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 2.46625
SEZ6L seizure related 6 homolog (mouse)-like 2.46607
PPP1R3C protein phosphatase 1, regulatory subunit 3C 2.46
FFAR2 free fatty acid receptor 2 2.4599
PRH1 proline-rich protein HaeIII subfamily 1 2.4559
NEFM neurofilament, medium polypeptide 2.45085
NEUROD2 neuronal differentiation 2 2.4506
CEND1 cell cycle exit and neuronal differentiation 1 2.4484
LILRA6 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 2.4437
SNCB synuclein, beta 2.4381
ASCL1 achaete-scute family bHLH transcription factor 1 2.43545
THUMPD1 THUMP domain containing 1 2.43327
MPPED1 metallophosphoesterase domain containing 1 2.4228
GNRH2 gonadotropin-releasing hormone 2 2.419
DMBT1 deleted in malignant brain tumors 1 2.4168
UNKL unkempt family zinc finger-like 2.4008
MAGEF1 melanoma antigen family F1 2.3953
SYN1 synapsin I 2.38685
CAPN10 calpain 10 2.37555
KCNJ6 potassium channel, inwardly rectifying subfamily J, member 6 2.37505
RBP3 retinol binding protein 3, interstitial 2.3722
NUP153 nucleoporin 153kDa 2.34805
TXNL4B thioredoxin-like 4B 2.3324
AP3B2 adaptor-related protein complex 3, beta 2 subunit 2.3215
HEYL hes-related family bHLH transcription factor with YRPW motif-like 2.32055
KLF15 Kruppel-like factor 15 2.30245
SEC24B SEC24 family member B 2.28825
HOXC5 homeobox C5 2.2867
SMNDC1 survival motor neuron domain containing 1 2.27615
COL11A2 collagen, type XI, alpha 2 2.27603
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 2.27185
BDNF brain-derived neurotrophic factor 2.26775
PRDM12 PR domain containing 12 2.26325
TRPV4 transient receptor potential cation channel, subfamily V, member 4 2.2628
CHRM4 cholinergic receptor, muscarinic 4 2.25775
TMA16 translation machinery associated 16 homolog (S. cerevisiae) 2.24475
LDAF1 lipid droplet assembly factor 1 2.24465
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.2395
PAX9 paired box 9 2.2391
PTPRN protein tyrosine phosphatase, receptor type, N 2.2372
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.22935
PAX1 paired box 1 2.228
MTMR3 myotubularin related protein 3 2.22053
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.2185
PLCB4 phospholipase C, beta 4 2.21782
GNG4 guanine nucleotide binding protein (G protein), gamma 4 2.21585
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.21245
PAEP progestagen-associated endometrial protein 2.2018
MATN1 matrilin 1, cartilage matrix protein 2.20033
CACNG2 calcium channel, voltage-dependent, gamma subunit 2 2.19865
ALX4 ALX homeobox 4 2.19335
SNX4 sorting nexin 4 2.19035
RECQL RecQ helicase-like 2.18686
REEP2 receptor accessory protein 2 2.18365
NLRP1 NLR family, pyrin domain containing 1 2.18268
NGF nerve growth factor (beta polypeptide) 2.1817
CNN1 calponin 1, basic, smooth muscle 2.18115
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) 2.1761
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.17285
TMEM43 transmembrane protein 43 2.16955
PGP phosphoglycolate phosphatase 2.1635
STATH statherin 2.16025
ELF2 E74-like factor 2 (ets domain transcription factor) 2.15867
CNTFR ciliary neurotrophic factor receptor 2.15845
NEUROG1 neurogenin 1 2.1547
CHRM3 cholinergic receptor, muscarinic 3 2.15355
ZSCAN2 zinc finger and SCAN domain containing 2 2.1455
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 2.1413
CCNE2 cyclin E2 2.13805
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 2.13005
CHRNA2 cholinergic receptor, nicotinic, alpha 2 (neuronal) 2.1284
MYT1L myelin transcription factor 1-like 2.1261
CAMK2B calcium/calmodulin-dependent protein kinase II beta 2.12327
FNBP4 formin binding protein 4 2.11805
HAUS7 HAUS augmin-like complex, subunit 7 2.11628
SPI1 Spi-1 proto-oncogene 2.11505
COXFA4L2 cytochrome c oxidase hypoxia associated subunit FA4L2 2.11395
NFRKB nuclear factor related to kappaB binding protein 2.11303
BAZ1A bromodomain adjacent to zinc finger domain, 1A 2.1095
SMAD9 SMAD family member 9 2.1063
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 2.10615
TGM3 transglutaminase 3 2.10305
HSPB8 heat shock 22kDa protein 8 2.1018
TLE6 transducin-like enhancer of split 6 2.09815
CALCA calcitonin-related polypeptide alpha 2.09811
HARS1 histidyl-tRNA synthetase 1 2.08415
AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2.07885
SMN2 survival of motor neuron 2, centromeric 2.07865
JPH2 junctophilin 2 2.07295
GHSR growth hormone secretagogue receptor 2.07165
PSPN persephin 2.0677
KIF26B kinesin family member 26B 2.06695
NKX2-1 NK2 homeobox 1 2.06288
C1D C1D nuclear receptor corepressor 2.06175
IKZF4 IKAROS family zinc finger 4 (Eos) 2.05585
RAX retina and anterior neural fold homeobox 2.0526
TUBA3E tubulin, alpha 3e 2.04985
STEAP3 STEAP family member 3, metalloreductase 2.0461
PIWIL2 piwi-like RNA-mediated gene silencing 2 2.0409
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.033
DAGLA diacylglycerol lipase, alpha 2.0303
CEMP1 cementum protein 1 2.02535
GRAMD4 GRAM domain containing 4 2.0247
EVC Ellis van Creveld protein 2.0243
INA internexin neuronal intermediate filament protein, alpha 2.024
SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2.0135
RPF1 ribosome production factor 1 homolog (S. cerevisiae) 2.01295
TRAPPC4 trafficking protein particle complex 4 2.01058
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.00835
SMPD4 sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3) 2.00505
FGF6 fibroblast growth factor 6 2.00315

decreased expression

Symbol Name Standardized Value
MRPS16 mitochondrial ribosomal protein S16 -5.42085
CCDC86 coiled-coil domain containing 86 -5.09525
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -5.01685
KRT14 keratin 14, type I -5.0
TCTN1 tectonic family member 1 -4.86145
PUF60 poly-U binding splicing factor 60KDa -4.6646
HMG20B high mobility group 20B -4.61403
PCCB propionyl CoA carboxylase, beta polypeptide -3.49785
ASCC1 activating signal cointegrator 1 complex subunit 1 -3.40315
SCRIB scribbled planar cell polarity protein -3.255
MSMO1 methylsterol monooxygenase 1 -3.15085
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) -2.99465
FLNB filamin B, beta -2.99458
ANXA2 annexin A2 -2.95685
CHODL chondrolectin -2.8405
PMVK phosphomevalonate kinase -2.79255
SORBS3 sorbin and SH3 domain containing 3 -2.76813
SDF2L1 stromal cell-derived factor 2-like 1 -2.76285
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -2.71142
MSN moesin -2.6305
PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme -2.6202
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit -2.55325
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa -2.5516
ACP6 acid phosphatase 6, lysophosphatidic -2.53315
PARN poly(A)-specific ribonuclease -2.53015
TMPRSS3 transmembrane protease, serine 3 -2.52395
ARL2 ADP-ribosylation factor-like 2 -2.51665
PIH1D1 PIH1 domain containing 1 -2.50895
SYNM synemin, intermediate filament protein -2.4946
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9 -2.4787
CLIP4 CAP-GLY domain containing linker protein family, member 4 -2.42615
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -2.42425
NELFE negative elongation factor complex member E -2.41595
GPM6B glycoprotein M6B -2.40224
NES nestin -2.39885
PDIA6 protein disulfide isomerase family A, member 6 -2.39762
SNX24 sorting nexin 24 -2.38535
PPP1R13L protein phosphatase 1, regulatory subunit 13 like -2.3799
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -2.3635
TMEM254 transmembrane protein 254 -2.3554
MICU1 mitochondrial calcium uptake 1 -2.3333
BHLHE41 basic helix-loop-helix family, member e41 -2.3288
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -2.31155
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 -2.29635
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 -2.2959
SLC17A5 solute carrier family 17 (acidic sugar transporter), member 5 -2.2889
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) -2.26995
SLCO1C1 solute carrier organic anion transporter family, member 1C1 -2.26715
PLAAT3 phospholipase A and acyltransferase 3 -2.25925
DHRS3 dehydrogenase/reductase (SDR family) member 3 -2.25885
SMAD2 SMAD family member 2 -2.25612
EPB41L4B erythrocyte membrane protein band 4.1 like 4B -2.2527
POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa -2.24885
BABAM2 BRISC and BRCA1 A complex member 2 -2.22932
PLIN1 perilipin 1 -2.2276
INTS6 integrator complex subunit 6 -2.2254
KLK5 kallikrein-related peptidase 5 -2.21555
USP18 ubiquitin specific peptidase 18 -2.2124
DAD1 defender against cell death 1 -2.2022
ADIPOQ adiponectin, C1Q and collagen domain containing -2.2004
COX8A cytochrome c oxidase subunit VIIIA (ubiquitous) -2.19145
ANG angiogenin, ribonuclease, RNase A family, 5 -2.1913
UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17 -2.1891
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae) -2.188
PREB prolactin regulatory element binding -2.15865
AGBL5 ATP/GTP binding protein-like 5 -2.1558
ATRAID all-trans retinoic acid-induced differentiation factor -2.1518
KLRC4-KLRK1 KLRC4-KLRK1 readthrough -2.1374
NDUFS2 NADH dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase) -2.12235
RHOF ras homolog family member F (in filopodia) -2.1176
TMEM214 transmembrane protein 214 -2.11715
ERMP1 endoplasmic reticulum metallopeptidase 1 -2.089
P2RX4 purinergic receptor P2X, ligand gated ion channel, 4 -2.07815
AURKB aurora kinase B -2.06965
GPX4 glutathione peroxidase 4 -2.06935
TRAPPC6A trafficking protein particle complex 6A -2.05625
IL32 interleukin 32 -2.04535
HTRA2 HtrA serine peptidase 2 -2.04247
CHI3L2 chitinase 3-like 2 -2.03715
ADA adenosine deaminase -2.03367
FAM114A2 family with sequence similarity 114, member A2 -2.02945
PHF11 PHD finger protein 11 -2.02435
FBXW4 F-box and WD repeat domain containing 4 -2.02005
PHF20L1 PHD finger protein 20-like 1 -2.0156
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) -2.01225
MVP major vault protein -2.00435