CRCGN017_MCF10A.TP53.M_24H:A09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acetohexamide 11.19 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:A09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.34513
SPAG4 sperm associated antigen 4 3.9955
AGR2 anterior gradient 2 3.3438
COMP cartilage oligomeric matrix protein 3.31275
LGMN legumain 3.1228
CHN1 chimerin 1 2.8529
TPD52L2 tumor protein D52-like 2 2.4562
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 2.44677
KDM5A lysine (K)-specific demethylase 5A 2.43845
NRBF2 nuclear receptor binding factor 2 2.29585
GLIPR1 GLI pathogenesis-related 1 2.0017

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -5.39675
TEX10 testis expressed 10 -4.59115
PRPF4 pre-mRNA processing factor 4 -4.41197
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.81432
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.59713
PSIP1 PC4 and SFRS1 interacting protein 1 -3.51177
THAP11 THAP domain containing 11 -3.4722
SLC31A1 solute carrier family 31 (copper transporter), member 1 -3.36405
RALGDS ral guanine nucleotide dissociation stimulator -2.95073
KRT14 keratin 14, type I -2.729
F8A2 coagulation factor VIII-associated 2 -2.4299
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.3764
NMRK1 nicotinamide riboside kinase 1 -2.3591
RABEPK Rab9 effector protein with kelch motifs -2.3161
GDI1 GDP dissociation inhibitor 1 -2.3113
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -2.2848
SIGLEC15 sialic acid binding Ig-like lectin 15 -2.2263
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase -2.21965
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.21895
FKBP15 FK506 binding protein 15, 133kDa -2.19812
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.1837
PPP6C protein phosphatase 6, catalytic subunit -2.17153
PKD2L1 polycystic kidney disease 2-like 1 -2.1653
MUC7 mucin 7, secreted -2.1324
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.1106
UBTD1 ubiquitin domain containing 1 -2.10215
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain -2.09235
SEC61B Sec61 beta subunit -2.0859
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.05695
TRIM32 tripartite motif containing 32 -2.0306