CRCGN017_MCF10A.TP53.M_24H:A19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenzo[a,l]pyrene 97.23 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

34 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:A19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SSBP2 single-stranded DNA binding protein 2 5.69145
C2CD2 C2 calcium-dependent domain containing 2 4.5756
VAV3 vav 3 guanine nucleotide exchange factor 4.519
ADAM10 ADAM metallopeptidase domain 10 4.28298
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 4.1059
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.75615
TGFB3 transforming growth factor, beta 3 2.75375
DPH2 DPH2 homolog (S. cerevisiae) 2.69675
RFNG RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 2.59915
CRELD2 cysteine-rich with EGF-like domains 2 2.5939
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 2.4841
DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 2.4234
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2.42025
ACAA1 acetyl-CoA acyltransferase 1 2.39075
DUS1L dihydrouridine synthase 1-like (S. cerevisiae) 2.12645
CGRRF1 cell growth regulator with ring finger domain 1 2.10595
MINDY2 MINDY lysine 48 deubiquitinase 2 2.05923
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 2.0448
IGLL1 immunoglobulin lambda-like polypeptide 1 2.0418
GSTZ1 glutathione S-transferase zeta 1 2.02485

decreased expression

Symbol Name Standardized Value
NPDC1 neural proliferation, differentiation and control, 1 -5.1411
PRPF4 pre-mRNA processing factor 4 -4.83445
HMG20B high mobility group 20B -3.90305
ATF5 activating transcription factor 5 -3.55815
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -3.4512
SORBS3 sorbin and SH3 domain containing 3 -3.0165
NANS N-acetylneuraminic acid synthase -2.9958
NUP93 nucleoporin 93kDa -2.84335
MRPL18 mitochondrial ribosomal protein L18 -2.66725
PIH1D1 PIH1 domain containing 1 -2.6168
RAD51C RAD51 paralog C -2.29982
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.1106
GRN granulin -2.04872
BDH1 3-hydroxybutyrate dehydrogenase, type 1 -2.0208