CRCGN017_MCF10A.TP53.M_24H:A20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description dibenzo[a,l]pyrene 32.41 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

126 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:A20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GFOD1 glucose-fructose oxidoreductase domain containing 1 6.69994
ACAA1 acetyl-CoA acyltransferase 1 4.6508
KDM5D lysine (K)-specific demethylase 5D 3.94572
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.85838
HBA1 hemoglobin, alpha 1 3.85162
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.43659
TYW2 tRNA wybutosine-synthesizing protein 2 3.31706
MSRA methionine sulfoxide reductase A 3.31008
WASHC5 WASH complex subunit 5 3.24998
VPS45 vacuolar protein sorting 45 homolog (S. cerevisiae) 3.01016
HBB hemoglobin, beta 2.96951
USP9Y ubiquitin specific peptidase 9, Y-linked 2.96136
NOL11 nucleolar protein 11 2.87851
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.83521
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.79883
GZMH granzyme H (cathepsin G-like 2, protein h-CCPX) 2.79117
TBC1D31 TBC1 domain family, member 31 2.73506
ZFY zinc finger protein, Y-linked 2.71787
PYCR1 pyrroline-5-carboxylate reductase 1 2.69964
VCY1B variable charge, Y-linked 1B 2.66984
DENND2D DENN/MADD domain containing 2D 2.64765
CCDC86 coiled-coil domain containing 86 2.62192
CD160 CD160 molecule 2.59442
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled 2.5504
PLS1 plastin 1 2.43431
STK32B serine/threonine kinase 32B 2.43202
PDZRN4 PDZ domain containing ring finger 4 2.42251
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.41907
GPHRA golgi pH regulator A 2.4008
GIPC1 GIPC PDZ domain containing family, member 1 2.3954
HSPB6 heat shock protein, alpha-crystallin-related, B6 2.3671
TACR2 tachykinin receptor 2 2.33872
RAP1A RAP1A, member of RAS oncogene family 2.32061
ZSCAN16 zinc finger and SCAN domain containing 16 2.30563
BCHE butyrylcholinesterase 2.30491
ZDHHC18 zinc finger, DHHC-type containing 18 2.2946
AKT1 v-akt murine thymoma viral oncogene homolog 1 2.29047
CRTAM cytotoxic and regulatory T cell molecule 2.28317
TNIP2 TNFAIP3 interacting protein 2 2.27075
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.24192
NT5DC2 5'-nucleotidase domain containing 2 2.24056
TTLL12 tubulin tyrosine ligase-like family member 12 2.22329
ATP6V0E2 ATPase, H+ transporting V0 subunit e2 2.22235
IL2RB interleukin 2 receptor, beta 2.18898
KLRF1 killer cell lectin-like receptor subfamily F, member 1 2.1793
KLRD1 killer cell lectin-like receptor subfamily D, member 1 2.15079
C1S complement component 1, s subcomponent 2.13735
TNIP3 TNFAIP3 interacting protein 3 2.13503
MEX3D mex-3 RNA binding family member D 2.12457
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.12256
DCAF6 DDB1 and CUL4 associated factor 6 2.12022
STAP1 signal transducing adaptor family member 1 2.09571
YES1 YES proto-oncogene 1, Src family tyrosine kinase 2.08588
TGM3 transglutaminase 3 2.08409
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 2.08203
TUBB4A tubulin, beta 4A class IVa 2.07874
PGGHG protein-glucosylgalactosylhydroxylysine glucosidase 2.07161
FAM117A family with sequence similarity 117, member A 2.06318
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.05058
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9 2.04173
TK1 thymidine kinase 1, soluble 2.03963
KLRC4-KLRK1 KLRC4-KLRK1 readthrough 2.03958
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.02914
EN2 engrailed homeobox 2 2.02365
DUSP14 dual specificity phosphatase 14 2.02362
PRELID3B PRELI domain containing 3B 2.01714
LAG3 lymphocyte-activation gene 3 2.01569
HMG20B high mobility group 20B 2.01446
AMDHD2 amidohydrolase domain containing 2 2.00408

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -6.5542
PRPF4 pre-mRNA processing factor 4 -5.36011
OXA1L oxidase (cytochrome c) assembly 1-like -4.79049
COG7 component of oligomeric golgi complex 7 -4.7749
STXBP2 syntaxin binding protein 2 -3.84392
PUDP pseudouridine 5'-phosphatase -3.71215
RPIA ribose 5-phosphate isomerase A -3.6675
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.29287
IGFBP7 insulin-like growth factor binding protein 7 -3.14022
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -3.07253
ZDHHC7 zinc finger, DHHC-type containing 7 -2.93403
CSNK1A1 casein kinase 1, alpha 1 -2.88034
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -2.87563
RPN1 ribophorin I -2.83898
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.78494
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.7638
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.72841
SMC1A structural maintenance of chromosomes 1A -2.72212
UBA1 ubiquitin-like modifier activating enzyme 1 -2.70544
PRPS2 phosphoribosyl pyrophosphate synthetase 2 -2.66724
KIF20A kinesin family member 20A -2.65683
EIF3CL eukaryotic translation initiation factor 3, subunit C-like -2.64193
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.62186
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -2.61131
QARS1 glutaminyl-tRNA synthetase 1 -2.6103
USP9X ubiquitin specific peptidase 9, X-linked -2.60439
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.60316
DHRS7B dehydrogenase/reductase (SDR family) member 7B -2.59506
SNAPC1 small nuclear RNA activating complex, polypeptide 1, 43kDa -2.54984
DSG2 desmoglein 2 -2.4954
SPAG5 sperm associated antigen 5 -2.42753
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 -2.37941
PNPLA4 patatin-like phospholipase domain containing 4 -2.37025
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.30727
ZNF516 zinc finger protein 516 -2.2922
PITPNM1 phosphatidylinositol transfer protein, membrane-associated 1 -2.29054
IPP intracisternal A particle-promoted polypeptide -2.28068
PDZD8 PDZ domain containing 8 -2.27271
MSN moesin -2.26591
FMNL1 formin-like 1 -2.23387
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.18896
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.17749
ACTA2 actin, alpha 2, smooth muscle, aorta -2.1663
ILK integrin-linked kinase -2.1389
TM9SF2 transmembrane 9 superfamily member 2 -2.1298
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.12155
ADD3 adducin 3 (gamma) -2.11693
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD) -2.11489
TNS4 tensin 4 -2.10228
STRA6 stimulated by retinoic acid 6 -2.07966
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.06404
IGBP1 immunoglobulin (CD79A) binding protein 1 -2.06171
LAS1L LAS1-like (S. cerevisiae) -2.04713
TRAPPC12 trafficking protein particle complex 12 -2.03599
TTF1 transcription termination factor, RNA polymerase I -2.02304
PLIN3 perilipin 3 -2.01099
GLB1L2 galactosidase, beta 1-like 2 -2.0108