CRCGN017_MCF10A.TP53.M_24H:A24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description ammonium-perfluorocaprylate 11.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

91 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:A24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 6.85461
CNRIP1 cannabinoid receptor interacting protein 1 4.36064
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.16383
ZBTB35 zinc finger and BTB domain containing 35 2.9683
ADRB2 adrenoceptor beta 2, surface 2.85896
IFT52 intraflagellar transport 52 2.74374
PEX11A peroxisomal biogenesis factor 11 alpha 2.64973
SPPL2A signal peptide peptidase like 2A 2.62857
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae) 2.5693
PPIH peptidylprolyl isomerase H (cyclophilin H) 2.53693
LYRM1 LYR motif containing 1 2.52666
TBPL1 TBP-like 1 2.51584
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.48881
GTF2E1 general transcription factor IIE, polypeptide 1, alpha 56kDa 2.47921
TOMM34 translocase of outer mitochondrial membrane 34 2.39998
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.36966
SP3 Sp3 transcription factor 2.35599
COQ8A coenzyme Q8A 2.34668
E2F6 E2F transcription factor 6 2.34478
NRBF2 nuclear receptor binding factor 2 2.33166
MRPL48 mitochondrial ribosomal protein L48 2.33077
CGRRF1 cell growth regulator with ring finger domain 1 2.25879
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme 2.2486
SF3B5 splicing factor 3b, subunit 5, 10kDa 2.20931
POLR2G polymerase (RNA) II (DNA directed) polypeptide G 2.15247
EIF4A3 eukaryotic translation initiation factor 4A3 2.13484
EIF6 eukaryotic translation initiation factor 6 2.12268
ATMIN ATM interactor 2.11185
MEPCE methylphosphate capping enzyme 2.09633
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 2.09057
DPYSL2 dihydropyrimidinase-like 2 2.08521
MEAF6 MYST/Esa1-associated factor 6 2.08299
MZT2B mitotic spindle organizing protein 2B 2.06172
INTS6 integrator complex subunit 6 2.0616
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 2.05653
ZNF410 zinc finger protein 410 2.03769
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) 2.0187
TBCB tubulin folding cofactor B 2.01375
TRAPPC2L trafficking protein particle complex 2-like 2.0047

decreased expression

Symbol Name Standardized Value
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.38719
TM9SF3 transmembrane 9 superfamily member 3 -3.92414
FASTKD5 FAST kinase domains 5 -3.5928
HMG20B high mobility group 20B -3.39461
IFRD2 interferon-related developmental regulator 2 -2.85845
PARP2 poly (ADP-ribose) polymerase 2 -2.67057
BAG3 BCL2-associated athanogene 3 -2.56003
RBM34 RNA binding motif protein 34 -2.54568
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.52162
TENT4A terminal nucleotidyltransferase 4A -2.48687
TAL1 T-cell acute lymphocytic leukemia 1 -2.46357
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -2.44251
FHIT fragile histidine triad -2.41345
BMP2 bone morphogenetic protein 2 -2.39156
CALY calcyon neuron-specific vesicular protein -2.38245
KDM3A lysine (K)-specific demethylase 3A -2.38103
LRPAP1 low density lipoprotein receptor-related protein associated protein 1 -2.34691
BCL2L2 BCL2-like 2 -2.33471
NCSTN nicastrin -2.32926
BPHL biphenyl hydrolase-like (serine hydrolase) -2.30799
CAPN15 calpain 15 -2.29896
SH3GL2 SH3-domain GRB2-like 2 -2.2715
NCLN nicalin -2.26005
EPB42 erythrocyte membrane protein band 4.2 -2.22576
GMPR guanosine monophosphate reductase -2.20388
COG7 component of oligomeric golgi complex 7 -2.19623
CRELD1 cysteine-rich with EGF-like domains 1 -2.19013
SLC22A11 solute carrier family 22 (organic anion/urate transporter), member 11 -2.18696
ACOT13 acyl-CoA thioesterase 13 -2.16879
NIT1 nitrilase 1 -2.1678
SLC13A1 solute carrier family 13 (sodium/sulfate symporter), member 1 -2.16514
MMRN2 multimerin 2 -2.16216
SV2A synaptic vesicle glycoprotein 2A -2.13454
ACY1 aminoacylase 1 -2.12388
ACOX2 acyl-CoA oxidase 2, branched chain -2.12155
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 -2.10429
GDF7 growth differentiation factor 7 -2.10286
TCTA T-cell leukemia translocation altered -2.08394
SCFD1 sec1 family domain containing 1 -2.07134
AIM2 absent in melanoma 2 -2.06385
MSH5 mutS homolog 5 -2.05615
GBP2 guanylate binding protein 2, interferon-inducible -2.05605
RUSF1 RUS family member 1 -2.05192
PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 -2.03919
ITGB7 integrin, beta 7 -2.03896
TCEAL2 transcription elongation factor A (SII)-like 2 -2.03591
SLC6A13 solute carrier family 6 (neurotransmitter transporter), member 13 -2.03467
TRPM3 transient receptor potential cation channel, subfamily M, member 3 -2.0308
GABRB1 gamma-aminobutyric acid (GABA) A receptor, beta 1 -2.02991
ATP11B ATPase, class VI, type 11B -2.02905
GATA1 GATA binding protein 1 (globin transcription factor 1) -2.00824
HYI hydroxypyruvate isomerase (putative) -2.00398