CRCGN017_MCF10A.TP53.M_24H:B04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:B04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 5.32708
SNAP25 synaptosomal-associated protein, 25kDa 4.85062
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.40095
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.19984
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.91641
AGR2 anterior gradient 2 3.64521
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 3.25731
TPD52L2 tumor protein D52-like 2 2.61914
TBPL1 TBP-like 1 2.35129
EXTL2 exostosin-like glycosyltransferase 2 2.28489
STMN2 stathmin 2 2.21629
NSG2 neuronal vesicle trafficking associated 2 2.20783
NEFH neurofilament, heavy polypeptide 2.14624
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.05281
ELP4 elongator acetyltransferase complex subunit 4 2.03146
NUP85 nucleoporin 85kDa 2.03084

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -3.53095
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.92733
HYI hydroxypyruvate isomerase (putative) -2.42282
HCK HCK proto-oncogene, Src family tyrosine kinase -2.30395
TOMM70 translocase of outer mitochondrial membrane 70 -2.19688
ATP5F1E ATP synthase F1 subunit epsilon -2.15133
BAX BCL2-associated X protein -2.13944
MNX1 motor neuron and pancreas homeobox 1 -2.09316
CTSH cathepsin H -2.05646
CYB5R2 cytochrome b5 reductase 2 -2.04947
KLK1 kallikrein 1 -2.03845
DRC4 dynein regulatory complex subunit 4 -2.01218
PIGP phosphatidylinositol glycan anchor biosynthesis, class P -2.01214