CRCGN017_MCF10A.TP53.M_24H:B06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description DMSO perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

32 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:B06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
E2F2 E2F transcription factor 2 3.30093
SSBP2 single-stranded DNA binding protein 2 3.1203
SNAP25 synaptosomal-associated protein, 25kDa 3.07773
KDM5D lysine (K)-specific demethylase 5D 3.01707
CCL2 chemokine (C-C motif) ligand 2 3.00967
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.68533
FZD1 frizzled class receptor 1 2.66143
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.26977
RPH3A rabphilin 3A 2.26043
NSG2 neuronal vesicle trafficking associated 2 2.24403
SYN1 synapsin I 2.21213
USP9Y ubiquitin specific peptidase 9, Y-linked 2.14778
GARRE1 granule associated Rac and RHOG effector 1 2.14663
ATP6V1G2 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 2.12617
ADGRB3 adhesion G protein-coupled receptor B3 2.11627
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.11383
AGR2 anterior gradient 2 2.10937
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.0994
PCSK2 proprotein convertase subtilisin/kexin type 2 2.06365
CNRIP1 cannabinoid receptor interacting protein 1 2.0556
STMN2 stathmin 2 2.02143
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.01855

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -3.22947
YME1L1 YME1-like 1 ATPase -3.17886
LYPLA1 lysophospholipase I -3.01218
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.49823
THAP11 THAP domain containing 11 -2.3727
APEH acylaminoacyl-peptide hydrolase -2.2113
KDM5C lysine (K)-specific demethylase 5C -2.14983
BAD BCL2-associated agonist of cell death -2.11007
IFRD2 interferon-related developmental regulator 2 -2.0446
TMEM115 transmembrane protein 115 -2.01343