CRCGN017_MCF10A.TP53.M_24H:B07 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5,7-dichloro-4-(4-fluorophenoxy)quinoline 102.9 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

102 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:B07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 5.97461
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.76371
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 4.75922
HMOX1 heme oxygenase 1 4.4892
SNAP25 synaptosomal-associated protein, 25kDa 4.04549
WFS1 Wolfram syndrome 1 (wolframin) 3.88206
UBQLN2 ubiquilin 2 3.52706
STAP2 signal transducing adaptor family member 2 3.18502
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.70625
ELP4 elongator acetyltransferase complex subunit 4 2.66463
HEXB hexosaminidase B (beta polypeptide) 2.57038
GLRX glutaredoxin (thioltransferase) 2.56057
C5 complement component 5 2.55472
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.54039
AARS1 alanyl-tRNA synthetase 1 2.5077
TXNRD1 thioredoxin reductase 1 2.48159
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.41167
PPP2R3B protein phosphatase 2, regulatory subunit B'', beta 2.38285
HOXA5 homeobox A5 2.37767
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.36762
TBX2 T-box 2 2.32504
UROS uroporphyrinogen III synthase 2.32207
PNKP polynucleotide kinase 3'-phosphatase 2.29785
PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 2.28558
BPNT1 3'(2'), 5'-bisphosphate nucleotidase 1 2.26731
NRBF2 nuclear receptor binding factor 2 2.25146
DUSP2 dual specificity phosphatase 2 2.21651
TSKU tsukushi, small leucine rich proteoglycan 2.21038
PYCR1 pyrroline-5-carboxylate reductase 1 2.12422
ENTR1 endosome associated trafficking regulator 1 2.07188
SV2C synaptic vesicle glycoprotein 2C 2.06635
DENND4B DENN/MADD domain containing 4B 2.05633
TTC38 tetratricopeptide repeat domain 38 2.0295
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 2.02641
ZMAT5 zinc finger, matrin-type 5 2.01875
HDLBP high density lipoprotein binding protein 2.01205

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -5.36492
TNIP1 TNFAIP3 interacting protein 1 -4.93835
ENOPH1 enolase-phosphatase 1 -4.36924
MSN moesin -3.52637
GOLT1B golgi transport 1B -3.29149
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -3.25523
TRAF1 TNF receptor-associated factor 1 -3.20536
MSMO1 methylsterol monooxygenase 1 -3.19911
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.09453
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.0924
ATF5 activating transcription factor 5 -2.9929
NFIL3 nuclear factor, interleukin 3 regulated -2.82785
MGRN1 mahogunin ring finger 1, E3 ubiquitin protein ligase -2.78842
DCTN4 dynactin 4 (p62) -2.74242
CAV2 caveolin 2 -2.71446
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.59443
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.57573
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.52094
PRR15L proline rich 15-like -2.47174
MVP major vault protein -2.45422
CYP20A1 cytochrome P450, family 20, subfamily A, polypeptide 1 -2.44241
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 -2.42115
CHMP4B charged multivesicular body protein 4B -2.4174
CAVIN2 caveolae associated protein 2 -2.36487
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.35317
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.35234
GBE1 glucan (1,4-alpha-), branching enzyme 1 -2.35209
GP1BA glycoprotein Ib (platelet), alpha polypeptide -2.31842
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.31541
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase -2.26203
CA2 carbonic anhydrase II -2.24829
SNRPE small nuclear ribonucleoprotein polypeptide E -2.23994
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.2356
GPBP1L1 GC-rich promoter binding protein 1-like 1 -2.2313
BAG4 BCL2-associated athanogene 4 -2.20523
DCTN6 dynactin 6 -2.20044
MSRB1 methionine sulfoxide reductase B1 -2.19307
BIRC3 baculoviral IAP repeat containing 3 -2.17222
BCAP29 B-cell receptor-associated protein 29 -2.16343
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa) -2.1569
TUBA4A tubulin, alpha 4a -2.14842
LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 -2.14542
SEC61G Sec61 gamma subunit -2.13823
COG7 component of oligomeric golgi complex 7 -2.1218
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.11366
MRPL39 mitochondrial ribosomal protein L39 -2.10881
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.10453
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -2.10214
CCNC cyclin C -2.10162
GADD45B growth arrest and DNA-damage-inducible, beta -2.09561
MRPL49 mitochondrial ribosomal protein L49 -2.09501
KLK8 kallikrein-related peptidase 8 -2.09265
LARP7 La ribonucleoprotein domain family, member 7 -2.09151
INSIG1 insulin induced gene 1 -2.08157
CLCNKA chloride channel, voltage-sensitive Ka -2.07782
RAB11FIP1 RAB11 family interacting protein 1 (class I) -2.05874
DSG1 desmoglein 1 -2.04969
TCTA T-cell leukemia translocation altered -2.04956
CHPT1 choline phosphotransferase 1 -2.03602
ADRB2 adrenoceptor beta 2, surface -2.02671
PRDM4 PR domain containing 4 -2.02531
ZDHHC6 zinc finger, DHHC-type containing 6 -2.01197
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.01168
ALDOC aldolase C, fructose-bisphosphate -2.01161
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -2.01119
COPS4 COP9 signalosome subunit 4 -2.00755