CRCGN017_MCF10A.TP53.M_24H:B09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 5,7-dichloro-4-(4-fluorophenoxy)quinoline 11.43 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:B09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCP110 centriolar coiled coil protein 110kDa 4.89411
EAPP E2F-associated phosphoprotein 4.58255
KLHL21 kelch-like family member 21 4.52146
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.33744
ZMIZ1 zinc finger, MIZ-type containing 1 3.03219
CHN1 chimerin 1 2.97944
HOXA5 homeobox A5 2.54373
PTPRK protein tyrosine phosphatase, receptor type, K 2.33296
CTTN cortactin 2.2087
ANPEP alanyl (membrane) aminopeptidase 2.05891
PDGFA platelet-derived growth factor alpha polypeptide 2.05838
FOXK2 forkhead box K2 2.05474

decreased expression

Symbol Name Standardized Value
YME1L1 YME1-like 1 ATPase -4.78829
ANXA2 annexin A2 -3.17418
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.15244
SH3D19 SH3 domain containing 19 -3.11453
ABI1 abl-interactor 1 -2.85026
MSMO1 methylsterol monooxygenase 1 -2.66228
KDM3A lysine (K)-specific demethylase 3A -2.4431
CD81 CD81 molecule -2.41975
GDI2 GDP dissociation inhibitor 2 -2.30328
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3 -2.28893
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.28753
GCH1 GTP cyclohydrolase 1 -2.24274
HKDC1 hexokinase domain containing 1 -2.18841
ANKZF1 ankyrin repeat and zinc finger domain containing 1 -2.14182
TLK2 tousled-like kinase 2 -2.09197
RANBP17 RAN binding protein 17 -2.06807
MTPAP mitochondrial poly(A) polymerase -2.04628
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.02496