CRCGN017_MCF10A.TP53.M_24H:B12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description n-ethyl-n-nitrosourea 11.96 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:B12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 5.07649
CCDC92 coiled-coil domain containing 92 4.25255
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.07004
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.84657
NOTCH1 notch 1 3.79564
FGFR4 fibroblast growth factor receptor 4 3.7955
COMP cartilage oligomeric matrix protein 3.31811
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.21569
ACAA1 acetyl-CoA acyltransferase 1 3.15844
CETN3 centrin, EF-hand protein, 3 2.80918
HBA1 hemoglobin, alpha 1 2.57637
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.47028
TBC1D31 TBC1 domain family, member 31 2.32069
PDZRN4 PDZ domain containing ring finger 4 2.28365
GAS2 growth arrest-specific 2 2.22221
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.22014
TOMM34 translocase of outer mitochondrial membrane 34 2.15098
MOCS2 molybdenum cofactor synthesis 2 2.09152
RHOH ras homolog family member H 2.06974
DUSP5 dual specificity phosphatase 5 2.06892
S100PBP S100P binding protein 2.05855
SCUBE2 signal peptide, CUB domain, EGF-like 2 2.03509
WWC2 WW and C2 domain containing 2 2.01665
PCDHB11 protocadherin beta 11 2.0079
PLAC8 placenta-specific 8 2.00165

decreased expression

Symbol Name Standardized Value
GOLT1B golgi transport 1B -5.10843
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.56508
CAB39 calcium binding protein 39 -3.55018
CD81 CD81 molecule -3.29298
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.0371
RECQL RecQ helicase-like -2.75844
CANT1 calcium activated nucleotidase 1 -2.59578
RALGDS ral guanine nucleotide dissociation stimulator -2.49897
WHR1 winged helix repair factor 1 -2.40019
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.35134
SLC39A7 solute carrier family 39 (zinc transporter), member 7 -2.32193
CCN3 cellular communication network factor 3 -2.31305
PYROXD1 pyridine nucleotide-disulphide oxidoreductase domain 1 -2.25306
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.22304
YIPF5 Yip1 domain family, member 5 -2.2206
ERGIC2 ERGIC and golgi 2 -2.11685
PLPP2 phospholipid phosphatase 2 -2.11543
TIMP1 TIMP metallopeptidase inhibitor 1 -2.11382
HSPA1A heat shock 70kDa protein 1A -2.09955
DUSP14 dual specificity phosphatase 14 -2.05048
YIF1A Yip1 interacting factor homolog A (S. cerevisiae) -2.04234
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 -2.00256