CRCGN017_MCF10A.TP53.M_24H:B17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description flutamide 33.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

62 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:B17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 3.98996
UBQLN2 ubiquilin 2 3.89696
CCL2 chemokine (C-C motif) ligand 2 3.71867
MAST2 microtubule associated serine/threonine kinase 2 3.00057
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 2.96979
HBB hemoglobin, beta 2.88822
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.67404
ZNF586 zinc finger protein 586 2.5989
GPER1 G protein-coupled estrogen receptor 1 2.56838
RTN2 reticulon 2 2.40804
IGHMBP2 immunoglobulin mu binding protein 2 2.36147
TBC1D31 TBC1 domain family, member 31 2.35456
MFHAS1 malignant fibrous histiocytoma amplified sequence 1 2.35028
RAI14 retinoic acid induced 14 2.2643
TPBG trophoblast glycoprotein 2.20087
ELOVL2 ELOVL fatty acid elongase 2 2.12574
PCDHB11 protocadherin beta 11 2.10558
IVNS1ABP influenza virus NS1A binding protein 2.07691
CLCC1 chloride channel CLIC-like 1 2.07689
ADA adenosine deaminase 2.05995
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.04014
NUP155 nucleoporin 155kDa 2.03212
HMGA2 high mobility group AT-hook 2 2.02164
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.00933

decreased expression

Symbol Name Standardized Value
TXNDC9 thioredoxin domain containing 9 -3.8313
ANXA2 annexin A2 -3.76093
FASTKD5 FAST kinase domains 5 -3.7267
TRAPPC3 trafficking protein particle complex 3 -3.58818
COG7 component of oligomeric golgi complex 7 -3.50891
CYCS cytochrome c, somatic -3.44082
STXBP2 syntaxin binding protein 2 -3.34274
BASP1 brain abundant, membrane attached signal protein 1 -3.2146
WASHC4 WASH complex subunit 4 -3.17511
MSMO1 methylsterol monooxygenase 1 -3.07355
GADD45B growth arrest and DNA-damage-inducible, beta -2.93347
COX6A1 cytochrome c oxidase subunit VIa polypeptide 1 -2.67781
ILK integrin-linked kinase -2.6778
CHIC2 cysteine-rich hydrophobic domain 2 -2.58309
RFC2 replication factor C (activator 1) 2, 40kDa -2.56539
TUBA4A tubulin, alpha 4a -2.53705
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.49163
PPP4C protein phosphatase 4, catalytic subunit -2.4867
SDF2 stromal cell-derived factor 2 -2.46621
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -2.464
IRAK4 interleukin-1 receptor-associated kinase 4 -2.42075
COMMD9 COMM domain containing 9 -2.32103
COX5B cytochrome c oxidase subunit Vb -2.25762
ZNF394 zinc finger protein 394 -2.19685
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7 -2.16509
NT5C2 5'-nucleotidase, cytosolic II -2.15105
ADRB2 adrenoceptor beta 2, surface -2.11437
RALGDS ral guanine nucleotide dissociation stimulator -2.08813
ZNF629 zinc finger protein 629 -2.08587
SCNN1B sodium channel, non voltage gated 1 beta subunit -2.07627
LOC102724594 splicing factor U2AF 35 kDa subunit -2.06784
TUBA3C tubulin, alpha 3c -2.02867
ZNF430 zinc finger protein 430 -2.02424
UQCRH ubiquinol-cytochrome c reductase hinge protein -2.02204
CD81 CD81 molecule -2.01881
MRPS15 mitochondrial ribosomal protein S15 -2.01723
RAP1B RAP1B, member of RAS oncogene family -2.01014
RBM48 RNA binding motif protein 48 -2.00311