CRCGN017_MCF10A.TP53.M_24H:B18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description flutamide 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

43 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:B18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 3.52771
SPAG4 sperm associated antigen 4 3.44008
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 3.34575
CNRIP1 cannabinoid receptor interacting protein 1 3.21201
CDCA4 cell division cycle associated 4 3.19219
DENND2D DENN/MADD domain containing 2D 3.18386
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 3.10245
MAN2B2 mannosidase, alpha, class 2B, member 2 2.83933
PEX11A peroxisomal biogenesis factor 11 alpha 2.56879
VAV3 vav 3 guanine nucleotide exchange factor 2.43559
EPCAM epithelial cell adhesion molecule 2.3574
CHEK1 checkpoint kinase 1 2.34831
F2R coagulation factor II (thrombin) receptor 2.3405
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.17575
SYBU syntabulin (syntaxin-interacting) 2.13593
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 2.13469
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.0511
CHSY1 chondroitin sulfate synthase 1 2.00464

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -3.68381
PLK1 polo-like kinase 1 -3.35426
HMG20B high mobility group 20B -3.33475
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.33456
TRAPPC3 trafficking protein particle complex 3 -3.10453
TUBB6 tubulin, beta 6 class V -3.10357
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -3.03384
CCNB2 cyclin B2 -2.696
PGAM4 phosphoglycerate mutase family member 4 -2.54412
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -2.46929
BSG basigin (Ok blood group) -2.41973
COL9A1 collagen, type IX, alpha 1 -2.37827
IFRD2 interferon-related developmental regulator 2 -2.35817
PRUNE2 prune homolog 2 (Drosophila) -2.30459
TROAP trophinin associated protein -2.29058
ACTC1 actin, alpha, cardiac muscle 1 -2.14764
PRPF4 pre-mRNA processing factor 4 -2.14221
SNCG synuclein, gamma (breast cancer-specific protein 1) -2.11844
AK8 adenylate kinase 8 -2.11348
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.08885
GRWD1 glutamate-rich WD repeat containing 1 -2.06453
DES desmin -2.05309
RND1 Rho family GTPase 1 -2.02816
FLNC filamin C, gamma -2.02036
ASCC1 activating signal cointegrator 1 complex subunit 1 -2.01449