CRCGN017_MCF10A.TP53.M_24H:B19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitropyrene 99.1 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:B19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BZW2 basic leucine zipper and W2 domains 2 4.25549
ABHD4 abhydrolase domain containing 4 3.18911
E2F2 E2F transcription factor 2 2.93911
ACAA1 acetyl-CoA acyltransferase 1 2.72007
CDCA4 cell division cycle associated 4 2.64948
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.46954
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.25679
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 2.15314
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.13302
RAB21 RAB21, member RAS oncogene family 2.13141
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 2.06823

decreased expression

Symbol Name Standardized Value
PCNA proliferating cell nuclear antigen -6.0306
DIPK1A divergent protein kinase domain 1A -3.90794
ATF5 activating transcription factor 5 -3.615
MRPS2 mitochondrial ribosomal protein S2 -3.4451
CCNB1 cyclin B1 -3.41839
PAEP progestagen-associated endometrial protein -2.93625
PUF60 poly-U binding splicing factor 60KDa -2.88746
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.76967
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.64866
COG2 component of oligomeric golgi complex 2 -2.4852
ECH1 enoyl CoA hydratase 1, peroxisomal -2.40291
DDRGK1 DDRGK domain containing 1 -2.34407
TMEM230 transmembrane protein 230 -2.29586
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.23781
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.21487
ATP11B ATPase, class VI, type 11B -2.18144
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.15962
MAVS mitochondrial antiviral signaling protein -2.05896
SEC16A SEC16 homolog A (S. cerevisiae) -2.04316
ZNF133 zinc finger protein 133 -2.00215