CRCGN017_MCF10A.TP53.M_24H:B20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-nitropyrene 33.03 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:B20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCDC92 coiled-coil domain containing 92 4.9353
CHEK1 checkpoint kinase 1 4.86427
ANO10 anoctamin 10 4.696
STIMATE STIM activating enhancer 4.43895
STK10 serine/threonine kinase 10 3.9437
FGFR4 fibroblast growth factor receptor 4 3.6907
ACAA1 acetyl-CoA acyltransferase 1 3.25563
MELK maternal embryonic leucine zipper kinase 3.02955
CNRIP1 cannabinoid receptor interacting protein 1 2.2406
PROS1 protein S (alpha) 2.19685
BAHD1 bromo adjacent homology domain containing 1 2.16175
TDRD7 tudor domain containing 7 2.1591
RPH3AL rabphilin 3A-like (without C2 domains) 2.15105
KAT7 K(lysine) acetyltransferase 7 2.1251
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.0887
RBKS ribokinase 2.0397
USP6NL USP6 N-terminal like 2.0316
GINS2 GINS complex subunit 2 (Psf2 homolog) 2.0081
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 2.0046

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -5.54025
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -5.1354
ADI1 acireductone dioxygenase 1 -4.90465
TRAPPC3 trafficking protein particle complex 3 -4.48308
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -3.26265
TKT transketolase -2.81145
TENT4A terminal nucleotidyltransferase 4A -2.7642
NGRN neugrin, neurite outgrowth associated -2.6635
QTRT1 queuine tRNA-ribosyltransferase 1 -2.5255
SF3A3 splicing factor 3a, subunit 3, 60kDa -2.4444
CEBPB CCAAT/enhancer binding protein (C/EBP), beta -2.3139
LSM14B LSM14B, SCD6 homolog B (S. cerevisiae) -2.27
CBX7 chromobox homolog 7 -2.2361
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1 -2.22727
PTPRF protein tyrosine phosphatase, receptor type, F -2.18353
KRT33A keratin 33A, type I -2.17215
ZNF217 zinc finger protein 217 -2.1514
MROH7 maestro heat-like repeat family member 7 -2.11595
TMBIM1 transmembrane BAX inhibitor motif containing 1 -2.1094
HBQ1 hemoglobin, theta 1 -2.09205
ASS1 argininosuccinate synthase 1 -2.0784
BPHL biphenyl hydrolase-like (serine hydrolase) -2.0637
KEL Kell blood group, metallo-endopeptidase -2.061
TCL1B T-cell leukemia/lymphoma 1B -2.0501
ZNF506 zinc finger protein 506 -2.0327
PDIA3 protein disulfide isomerase family A, member 3 -2.0274
HTR1D 5-hydroxytryptamine (serotonin) receptor 1D, G protein-coupled -2.01445
CLASRP CLK4-associating serine/arginine rich protein -2.0051