CRCGN017_MCF10A.TP53.M_24H:B24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-aminodiphenyl 10.94 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:B24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 7.71559
MAP7 microtubule-associated protein 7 3.60764
FKBP14 FK506 binding protein 14, 22 kDa 3.57358
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 3.44409
NCK2 NCK adaptor protein 2 3.30166
DENND2D DENN/MADD domain containing 2D 3.23297
OLFML2B olfactomedin-like 2B 3.08859
SYNGAP1 synaptic Ras GTPase activating protein 1 2.87503
CNRIP1 cannabinoid receptor interacting protein 1 2.6808
MEF2C myocyte enhancer factor 2C 2.63257
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.27427
CCNF cyclin F 2.09029
NPR2 natriuretic peptide receptor 2 2.08888
EXOSC8 exosome component 8 2.08139

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -3.4179
TENT4A terminal nucleotidyltransferase 4A -3.13927
BPHL biphenyl hydrolase-like (serine hydrolase) -2.70884
CORO1A coronin, actin binding protein, 1A -2.49583
VTN vitronectin -2.49474
TXNDC9 thioredoxin domain containing 9 -2.46897
GNAZ guanine nucleotide binding protein (G protein), alpha z polypeptide -2.44195
ITIH3 inter-alpha-trypsin inhibitor heavy chain 3 -2.3232
MEGF6 multiple EGF-like-domains 6 -2.26385
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 -2.25588
C8G complement component 8, gamma polypeptide -2.24971
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -2.17524
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -2.1751
LRRN2 leucine rich repeat neuronal 2 -2.10564
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.10021
CTSD cathepsin D -2.07656
GPR27 G protein-coupled receptor 27 -2.07169
AMBP alpha-1-microglobulin/bikunin precursor -2.06417
THAP11 THAP domain containing 11 -2.05304
SLC4A3 solute carrier family 4 (anion exchanger), member 3 -2.05131
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) -2.02313
CEP72 centrosomal protein 72kDa -2.01802
DIPK1A divergent protein kinase domain 1A -2.01647
ASGR1 asialoglycoprotein receptor 1 -2.00988
ADH1A alcohol dehydrogenase 1A (class I), alpha polypeptide -2.00245
SERPINF2 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2 -2.00005