CRCGN017_MCF10A.TP53.M_24H:C02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-diindolylmethane 33.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

108 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 5.52385
SPAG4 sperm associated antigen 4 4.9106
KDM5A lysine (K)-specific demethylase 5A 4.51883
GLRX glutaredoxin (thioltransferase) 3.84443
CEMIP2 cell migration inducing hyaluronidase 2 3.8337
KDM5D lysine (K)-specific demethylase 5D 3.6411
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 3.473
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.2959
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.26328
TSKU tsukushi, small leucine rich proteoglycan 3.1076
ACAA1 acetyl-CoA acyltransferase 1 3.08028
CDC25B cell division cycle 25B 3.0438
IL1B interleukin 1, beta 2.92593
PHGDH phosphoglycerate dehydrogenase 2.87228
GAA glucosidase, alpha; acid 2.86965
CTSL cathepsin L 2.86635
RBKS ribokinase 2.80718
ZMYM2 zinc finger, MYM-type 2 2.55795
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.52255
USP9Y ubiquitin specific peptidase 9, Y-linked 2.42015
RBM12B RNA binding motif protein 12B 2.39055
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 2.37135
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 2.35435
PROS1 protein S (alpha) 2.31375
IER3 immediate early response 3 2.3062
TRIB3 tribbles pseudokinase 3 2.30075
RAB5B RAB5B, member RAS oncogene family 2.29525
XPOT exportin, tRNA 2.29445
C1RL complement component 1, r subcomponent-like 2.2538
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.22732
CRTAP cartilage associated protein 2.1884
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 2.14845
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.1414
CD302 CD302 molecule 2.14125
RCN1 reticulocalbin 1, EF-hand calcium binding domain 2.11775
RPN1 ribophorin I 2.1028
EMC7 ER membrane protein complex subunit 7 2.0886
OLFML2B olfactomedin-like 2B 2.0824
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2.0763
R3HDM4 R3H domain containing 4 2.07422
NCK2 NCK adaptor protein 2 2.0624
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.06103
PRAF2 PRA1 domain family, member 2 2.0588
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.0479
CTBS chitobiase, di-N-acetyl- 2.03385
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 2.0295
PYCR1 pyrroline-5-carboxylate reductase 1 2.0094
INSIG1 insulin induced gene 1 2.0074
ACADVL acyl-CoA dehydrogenase, very long chain 2.00485

decreased expression

Symbol Name Standardized Value
PARP2 poly (ADP-ribose) polymerase 2 -5.09273
PCNA proliferating cell nuclear antigen -5.0
ADRB2 adrenoceptor beta 2, surface -4.086
SMC1A structural maintenance of chromosomes 1A -3.5977
GADD45B growth arrest and DNA-damage-inducible, beta -3.5538
PUDP pseudouridine 5'-phosphatase -3.1682
PRR15L proline rich 15-like -3.0739
REEP1 receptor accessory protein 1 -2.96805
SORBS3 sorbin and SH3 domain containing 3 -2.92685
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.79875
STMN1 stathmin 1 -2.63515
BRD7 bromodomain containing 7 -2.61275
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.58212
KDM6A lysine (K)-specific demethylase 6A -2.53237
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) -2.5045
GRWD1 glutamate-rich WD repeat containing 1 -2.50375
TUBB6 tubulin, beta 6 class V -2.4594
RGS2 regulator of G-protein signaling 2 -2.45695
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.4551
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.445
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.43043
CDCA8 cell division cycle associated 8 -2.4149
ELAC2 elaC ribonuclease Z 2 -2.38105
DCTPP1 dCTP pyrophosphatase 1 -2.37095
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.3575
KIF15 kinesin family member 15 -2.35255
UBA1 ubiquitin-like modifier activating enzyme 1 -2.35015
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.34825
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.33342
TOM1L2 target of myb1-like 2 (chicken) -2.32905
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.31519
NSFL1C NSFL1 (p97) cofactor (p47) -2.31297
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa -2.31035
PDLIM2 PDZ and LIM domain 2 (mystique) -2.27925
OSGEP O-sialoglycoprotein endopeptidase -2.26765
HTR3A 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic -2.23658
CENPX centromere protein X -2.23215
HS3ST2 heparan sulfate (glucosamine) 3-O-sulfotransferase 2 -2.21215
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.21145
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.18345
RAD51C RAD51 paralog C -2.17217
TBCC tubulin folding cofactor C -2.16935
GINS2 GINS complex subunit 2 (Psf2 homolog) -2.15195
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A -2.14725
STS steroid sulfatase (microsomal), isozyme S -2.13289
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.12815
KCNN1 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 1 -2.1279
ATRIP ATR interacting protein -2.1176
RAD54L2 RAD54-like 2 (S. cerevisiae) -2.0934
TCEA2 transcription elongation factor A (SII), 2 -2.0687
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 -2.05195
SAP30BP SAP30 binding protein -2.0501
SMAGP small cell adhesion glycoprotein -2.04485
ZNF219 zinc finger protein 219 -2.04325
HIRIP3 HIRA interacting protein 3 -2.03555
CTNNBL1 catenin, beta like 1 -2.01995
OXCT1 3-oxoacid CoA transferase 1 -2.00925
NASP nuclear autoantigenic sperm protein (histone-binding) -2.00627
ADISSP adipose secreted signaling protein -2.005